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Merck
CN

B1686

BIO

≥98% (HPLC), powder, GSK-3α/β inhibitor

别名:

(2’Z,3’E)-6-溴靛玉红-3′-肟, 6-BIO, 6BIO

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关于此项目

经验公式（希尔记法）:
C16H10BrN3O2
化学文摘社编号:
667463-62-9
分子量:
356.17
UNSPSC Code:
12352200
PubChem Substance ID:
24724412
NACRES:
NA.77
MDL number:
MFCD08705318

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产品名称

BIO, ≥98% (HPLC)

SMILES string

O\N=C1\C(Nc2ccccc12)=C3\C(=O)Nc4cc(Br)ccc34

InChI key

DDLZLOKCJHBUHD-WAVHTBQISA-N

InChI

1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18,22H,(H,19,21)/b15-13-,20-14+

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

dark red

solubility

DMSO: >5 mg/mL

shipped in

wet ice

storage temp.

2-8°C

Quality Level

100

相关类别

Application

6-溴靛玉红-3′-肟(BIO)已用于以下情形：
  • MTT 3-(4,5-二甲基噻唑-2- 基)-2,5-联苯四唑溴化物)细胞增殖实验
  • 胚胎干细胞(ESC)的培养基补充剂
  • 抑制人真皮乳头细胞(hDPC)中的糖原合成酶激酶3 β (GSK-3β)

Biochem/physiol Actions

6-溴靛玉红-3′-肟（BIO）是一种有效的、可逆的、ATP竞争性GSK-3α/β抑制剂，并且是第一种能够维持人和小鼠胚胎干细胞自我更新的药物。通过在无饲养层条件下用GSK-3抑制剂BIO处理，能够将人胚胎干细胞（hESC）维持在未分化状态。
BIO是一种有效的、选择性的、可逆的、ATP竞争性GSK-3α/β抑制剂。

Features and Benefits

《受体分类和信号转导》手册的 GSK-3 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物是激酶磷酸酶生物学研究推荐产品。点击此处 ，查看更多激酶磷酸酶生物学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

Legal Information

本品适用于 体外 研究和实验室用途，不得用于人类的任何 体内 或治疗用途、兽医应用或制造化学衍生物。

Packaging

空气敏感

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000384575
0000278882
0000384575
0000220374
0000220374

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Human placental extract exerts hair growth-promoting effects through the GSK-3beta signaling pathway in human dermal papilla cells
Kwon TR, et al.
International Journal of Molecular Medicine, 36(4), 1088-1096 (2015)
Andrew R Patterson et al.
Nature communications, 9(1), 430-430 (2018-02-01)
GTPase of immunity-associated protein 5 (Gimap5) is linked with lymphocyte survival, autoimmunity, and colitis, but its mechanisms of action are unclear. Here, we show that Gimap5 is essential for the inactivation of glycogen synthase kinase-3β (GSK3β) following T cell activation.
Anchel De Jaime-Soguero et al.
PLoS genetics, 13(3), e1006682-e1006682 (2017-03-28)
Understanding the mechanisms regulating cell cycle, proliferation and potency of pluripotent stem cells guarantees their safe use in the clinic. Embryonic stem cells (ESCs) present a fast cell cycle with a short G1 phase. This is due to the lack
Azuma Kimura et al.
Stem cell research, 24, 61-68 (2017-08-27)
While pancreatic islet transplantation achieves insulin independence in type 1 diabetes (T1D) patients, its widespread application is limited by donor tissue scarcity. Pancreatic progenitor cells (PPCs) give rise to all cell types in the pancreas during development. PPCs derived from
Disconnect between alcohol-induced alterations in chromatin structure and gene transcription in a mouse embryonic stem cell model of exposure
Veazey K, et al.
Alcohol, 60(23), 121-133 (2017)
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