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B1686

BIO

≥98% (HPLC), powder, GSK-3α/β inhibitor

别名:

(2’Z,3’E)-6-溴靛玉红-3′-肟, 6-BIO, 6BIO

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关于此项目

经验公式（希尔记法）:
C16H10BrN3O2
化学文摘社编号:
667463-62-9
分子量:
356.17
UNSPSC Code:
12352200
PubChem Substance ID:
24724412
NACRES:
NA.77
MDL number:
MFCD08705318
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
protect from light
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产品名称

BIO, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

dark red

solubility

DMSO: >5 mg/mL

shipped in

wet ice

storage temp.

2-8°C

SMILES string

O\N=C1\C(Nc2ccccc12)=C3\C(=O)Nc4cc(Br)ccc34

InChI

1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18,22H,(H,19,21)/b15-13-,20-14+

InChI key

DDLZLOKCJHBUHD-WAVHTBQISA-N

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相关类别

Application

6-溴靛玉红-3′-肟(BIO)已用于以下情形：
  • MTT 3-(4,5-二甲基噻唑-2- 基)-2,5-联苯四唑溴化物)细胞增殖实验
  • 胚胎干细胞(ESC)的培养基补充剂
  • 抑制人真皮乳头细胞(hDPC)中的糖原合成酶激酶3 β (GSK-3β)

Biochem/physiol Actions

6-溴靛玉红-3′-肟（BIO）是一种有效的、可逆的、ATP竞争性GSK-3α/β抑制剂，并且是第一种能够维持人和小鼠胚胎干细胞自我更新的药物。通过在无饲养层条件下用GSK-3抑制剂BIO处理，能够将人胚胎干细胞（hESC）维持在未分化状态。
BIO是一种有效的、选择性的、可逆的、ATP竞争性GSK-3α/β抑制剂。

Features and Benefits

该化合物是激酶磷酸酶生物学研究推荐产品。点击此处 ，查看更多激酶磷酸酶生物学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
《受体分类和信号转导》手册的 GSK-3 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

Packaging

空气敏感

Legal Information

本品适用于 体外 研究和实验室用途，不得用于人类的任何 体内 或治疗用途、兽医应用或制造化学衍生物。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000535631
0000535631
0000384575
0000278882
0000384575

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Anchel De Jaime-Soguero et al.
PLoS genetics, 13(3), e1006682-e1006682 (2017-03-28)
Understanding the mechanisms regulating cell cycle, proliferation and potency of pluripotent stem cells guarantees their safe use in the clinic. Embryonic stem cells (ESCs) present a fast cell cycle with a short G1 phase. This is due to the lack
Disconnect between alcohol-induced alterations in chromatin structure and gene transcription in a mouse embryonic stem cell model of exposure
Veazey K, et al.
Alcohol, 60(23), 121-133 (2017)
Tatsuki Ogasawara et al.
Scientific reports, 7(1), 8630-8630 (2017-08-19)
Pluripotent stem cell-derived cardiomyocytes show great promise in regenerating the heart after myocardial infarction; however, several uncertainties exist that must be addressed before clinical trials. One practical issue is graft survival following transplantation. Although a pro-survival cocktail with Matrigel has
Human placental extract exerts hair growth-promoting effects through the GSK-3beta signaling pathway in human dermal papilla cells
Kwon TR, et al.
International Journal of Molecular Medicine, 36(4), 1088-1096 (2015)
Xiang Qiu et al.
World journal of gastroenterology, 21(26), 8061-8072 (2015-07-18)
To investigate the therapeutic effects of lutein against non-alcoholic fatty liver disease (NAFLD) and the related underlying mechanism. After 9 d of acclimation to a constant temperature-controlled room (20 °C-22 °C) under 12 h light/dark cycles, male Sprague-Darley rats were randomly divided
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全球贸易项目编号

货号GTIN
B1686-25MG04061832444529
B1686-5MG04061833426319

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