B1760
苯并[a]芘
≥96% (HPLC)
别名:
3,4-苯并芘, 苯并[det]屈, 苯并芘
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关于此项目
经验公式（希尔记法）:
C20H12
化学文摘社编号:
分子量:
252.31
UNSPSC Code:
12352005
NACRES:
NA.25
PubChem Substance ID:
EC Number:
200-028-5
Beilstein/REAXYS Number:
1911333
MDL number:
Application
苯并(a)芘（PAH），是一种聚环芳烃污染物，在癌症实验模型中作为化学致癌剂。致癌作用取决于它的氧化反应，CYP1A1转化成苯并(a)芘二醇环氧化物，和DNA形成去嘌呤加成，解离形成坏疽性病变。苯并(a)芘是多环芳香烃受体（AhR）配体，它的一些生物效应，包括诱发CYP1A1，通过AHR活化调节。
signalword
Danger
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
flash_point_f
Not applicable
flash_point_c
Not applicable
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Muta. 1B - PBT - Repr. 1B - Skin Sens. 1 - vPvB
Yi-Chen Lin et al.
Antioxidants (Basel, Switzerland), 9(8) (2020-08-17)
Benzo[a]pyrene (B[a]P) is a polycyclic aromatic hydrocarbon formed by the incomplete combustion of organic matter. Environmental B[a]P contamination poses a serious health risk to many organisms because the pollutant may negatively affect many physiological systems. As such, chronic exposure to
Ariel Revel et al.
Journal of applied toxicology : JAT, 23(4), 255-261 (2003-07-29)
Benzo[a]pyrene (BaP) is an agonistic ligand for the aryl hydrocarbon receptor (AhR) and a major environmental carcinogen implicated in the aetiology of lung cancer through the induction of benzo[a]pyrene diol epoxidation (BPDE) and BPDE-DNA adducts. Because BaP metabolization requires cytochrome
Audrey Barranger et al.
Nanomaterials (Basel, Switzerland), 9(7) (2019-07-11)
This study aimed to assess the ecotoxicological effects of the interaction of fullerene (C60) and benzo[a]pyrene (B[a]P) on the marine mussel, Mytilus galloprovincialis. The uptake of nC60, B[a]P and mixtures of nC60 and B[a]P into tissues was confirmed by Gas
Yuji Fujita et al.
Bioorganic & medicinal chemistry, 18(3), 1194-1203 (2010-01-12)
The physiological role of aryl hydrocarbon receptor (AhR) is not yet fully understood, and investigation is hampered by the limited solubility of reported AhR ligands in aqueous media. To achieve improved solubility, we focused on our previous finding that planarity-disruption
Systematic identification of CDC34 that functions to stabilize EGFR and promote lung carcinogenesis.
Xin-Chun Zhao et al.
EBioMedicine, 53, 102689-102689 (2020-03-03)
How the oncoprotein epidermal growth factor receptor (EGFR) evades proteolytic degradation and accumulates in non-small cell lung cancer (NSCLC) remains unclear, and ubiquitin pathway genes (UPGs) that are critical to NSCLC needs to be systematically identified. A total of 696
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DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| B1760-250MG | 04061833426371 |
| B1760-100MG | 04061833426364 |
| B1760-1G | 04061835542826 |
| B1760-5G | 04061835512171 |
| B1760-500MG | 04061833426388 |
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