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Merck
CN

B2144

Boc-Tyr-D-Ala-Gly

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关于此项目

经验公式(希尔记法):
C19H27N3O7
化学文摘社编号:
分子量:
409.43
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
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storage temp.

−20°C

SMILES string

CC(NC(=O)C(Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(O)=O

Biochem/physiol Actions

Boc-Tyr-D-Ala-Gly is an N-terminal protected tripeptides useful in solid phase peptide synthesis (Boc-SPPS). Boc-Tyr-D-Ala-Gly may be used in the synthesis of opioid activity containing peptides such as biphalin molecule, enkephalins and tetrapeptide hydrazide.


存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Nigel P Pedersen et al.
Journal of neurophysiology, 106(2), 731-740 (2011-05-20)
The rostral ventromedial medulla (RVM) is an important site of opioid actions and forms part of an analgesic pathway that projects to the spinal cord. The neuronal mechanisms by which opioids act within this brain region remain unclear, particularly in
M Schnölzer et al.
International journal of peptide and protein research, 40(3-4), 180-193 (1992-09-01)
Simple, effective protocols have been developed for manual and machine-assisted Boc-chemistry solid phase peptide synthesis on polystyrene resins. These use in situ neutralization [i.e. neutralization simultaneous with coupling], high concentrations (> 0.2 M) of Boc-amino acid-OBt esters plus base for
Krisztina Csabafi et al.
Peptides, 32(8), 1656-1660 (2011-07-05)
The neuroendocrine and behavioral effects of Tyr-D-Ala-Gly-Phe-D-Nle-Arg-Phe (DADN), a more stable derivative of the endogenous opiate Met-enkephalin related peptide Met(5)-enkephalin-Arg(6)-Phe(7) were investigated in mice. The behavioral experiments consisted of monitoring the horizontal (square crossing) and vertical (rearing) locomotion in the