B2185
比索洛尔 半富马酸盐
≥98% (HPLC), β1-adrenoceptor antagonist, solid
别名:
1- [4-[[2-（1-甲基乙氧基）乙氧基]甲基]苯氧基] -3-[（1-甲基乙基）氨基] -2-丙醇 半富马酸盐
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选择尺寸
关于此项目
经验公式（希尔记法）:
C18H31NO4 · .5C4H4O4
化学文摘社编号:
分子量:
383.48
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
比索洛尔 半富马酸盐, ≥98% (HPLC), solid
质量水平
方案
≥98% (HPLC)
表单
solid
颜色
white
溶解性
DMSO: >20 mg/mL
创始人
Teva
SMILES字符串
OC(=O)\C=C\C(O)=O.CC(C)NCC(O)COc1ccc(COCCOC(C)C)cc1.CC(C)NCC(O)COc2ccc(COCCOC(C)C)cc2
InChI
1S/2C18H31NO4.C4H4O4/c2*1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h2*5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
InChI key
VMDFASMUILANOL-WXXKFALUSA-N
基因信息
human ... ADRB1(153)
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应用
比索洛尔富马酸盐已在心肌纤维化小鼠模型中用作β-肾上腺素能受体（β-AR）拮抗剂。
生化/生理作用
心脏选择性 β1-肾上腺素受体拮抗剂。
比索洛尔富马酸盐因其高生物利用度而可用于口服制剂。它还显示出了较长的消除半衰期。
特点和优势
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Repr. 2 - STOT RE 2
靶器官
Heart
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
A E Tattersfield et al.
British journal of clinical pharmacology, 18(3), 343-347 (1984-09-01)
Bisoprolol is a new beta-adrenoceptor antagonist which has shown beta-adrenoceptor selectivity in studies in isolated tissues. Bronchial and cardiac beta-adrenoceptor blockade were assessed in eight normal subjects before and after oral ingestion of placebo, bisoprolol 20 and 40 mg, metoprolol
Cardiac beta-adrenergic receptor activation mediates distinct and cell type-dependent changes in the expression and distribution of connexin 43
Zhang Y, et al.
Journal of Cellular and Molecular Medicine (2020)
Pharmacokinetics and metabolism of bisoprolol enantiomers in humans
Horikiri Y, et al.
Journal of Pharmaceutical Sciences, 87(3), 289-294 (1998)
Rubén M Maggio et al.
Journal of pharmaceutical and biomedical analysis, 72, 51-58 (2012-11-14)
The association of an on-line circulation system with a chemometrics-assisted UV detection strategy is described as a useful system to continuously monitor the dissolution of a pharmaceutical preparation containing two active ingredients, and as a tool for the simultaneous determination
Viktor Nagy
Orvosi hetilap, 154(44), 1731-1734 (2013-10-29)
The prevalence of chronic heart failure in Hungary is 1.6% in the adult population, but it occurs in 15-20% of subjects over 80 years of age. The base of treatment of heart failure is the blockade of the neuro-hormonal system
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