B2185
比索洛尔 半富马酸盐
≥98% (HPLC), β1-adrenoceptor antagonist, solid
别名:
1- [4-[[2-（1-甲基乙氧基）乙氧基]甲基]苯氧基] -3-[（1-甲基乙基）氨基] -2-丙醇 半富马酸盐
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选择尺寸
关于此项目
经验公式（希尔记法）:
C18H31NO4 · .5C4H4O4
化学文摘社编号:
分子量:
383.48
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
比索洛尔 半富马酸盐, ≥98% (HPLC), solid
SMILES string
OC(=O)\C=C\C(O)=O.CC(C)NCC(O)COc1ccc(COCCOC(C)C)cc1.CC(C)NCC(O)COc2ccc(COCCOC(C)C)cc2
InChI key
VMDFASMUILANOL-WXXKFALUSA-N
InChI
1S/2C18H31NO4.C4H4O4/c2*1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h2*5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: >20 mg/mL
originator
Teva
Quality Level
Gene Information
human ... ADRB1(153)
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Application
比索洛尔富马酸盐已在心肌纤维化小鼠模型中用作β-肾上腺素能受体（β-AR）拮抗剂。
Biochem/physiol Actions
心脏选择性 β1-肾上腺素受体拮抗剂。
比索洛尔富马酸盐因其高生物利用度而可用于口服制剂。它还显示出了较长的消除半衰期。
Features and Benefits
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2 - STOT RE 2
target_organs
Heart
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
此项目有
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A E Tattersfield et al.
British journal of clinical pharmacology, 18(3), 343-347 (1984-09-01)
Bisoprolol is a new beta-adrenoceptor antagonist which has shown beta-adrenoceptor selectivity in studies in isolated tissues. Bronchial and cardiac beta-adrenoceptor blockade were assessed in eight normal subjects before and after oral ingestion of placebo, bisoprolol 20 and 40 mg, metoprolol
Akira Sezai et al.
The Journal of thoracic and cardiovascular surgery, 144(5), 1241-1248 (2012-08-04)
We previously performed a trial of intravenous landiolol hydrochloride during and after cardiac surgery (the PASCAL trial) and demonstrated a preventive effect on postoperative atrial fibrillation (AF). In the present study, we investigated the efficacy of increasing the dose and
Rubén M Maggio et al.
Journal of pharmaceutical and biomedical analysis, 72, 51-58 (2012-11-14)
The association of an on-line circulation system with a chemometrics-assisted UV detection strategy is described as a useful system to continuously monitor the dissolution of a pharmaceutical preparation containing two active ingredients, and as a tool for the simultaneous determination
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