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B2186

BL-1249

≥98% (HPLC)

别名:

(5,6,7,8-Tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine

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关于此项目

经验公式（希尔记法）:
C17H17N5
化学文摘社编号:
18200-13-0
分子量:
291.35
NACRES:
NA.77
PubChem Substance ID:
24724415
UNSPSC Code:
12352200
MDL number:
MFCD08276915
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
protect from light
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Quality Segment

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

pink to brown

solubility

DMSO: ~17.5 mg/mL, H2O: insoluble

storage temp.

−20°C

SMILES string

C1CCc2c(C1)cccc2Nc3ccccc3-c4nnn[nH]4

InChI

1S/C17H17N5/c1-2-8-13-12(6-1)7-5-11-15(13)18-16-10-4-3-9-14(16)17-19-21-22-20-17/h3-5,7,9-11,18H,1-2,6,8H2,(H,19,20,21,22)

InChI key

YYNRZIFBTOUICE-UHFFFAOYSA-N

General description

BL-1249 is a non-steroid anti-inflammatory drug and an inhibitor of the cyclooxygenase (COX) enzyme.

Application

BL-1249 has been used:
  • as an activator of mechano-gated K2P channel in contracted mouse ileum and colon tissues
  • as a TWIK related potassium channel (TREK2) modulator and in U-2 OS osteosarcoma cell line
  • as a TREK1 and TREK2 activator in mice.

Biochem/physiol Actions

BL-1249 also activates TWIK related potassium channel 2 (TREK2). It interacts with K2P channel at the negatively charged activator site and modulates channel opening.
BL-1249 is a potassium TREK-1 channel activator.
BL-1249 is a putative activator of potassium TREK-1 channel.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形图

Exclamation mark
GHS07

警示词

Warning

Hazard Classifications

Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

存储类别

11 - Combustible Solids

怎么回事？

WGK 3

闪点 (F)

Not applicable

闪点 (°C)

Not applicable

PPE（个人防护设备）

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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