B2186
BL-1249
≥98% (HPLC)
别名:
(5,6,7,8-Tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C17H17N5
化学文摘社编号:
分子量:
291.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
protect from light
Quality Segment
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
pink to brown
solubility
DMSO: ~17.5 mg/mL, H2O: insoluble
storage temp.
−20°C
SMILES string
C1CCc2c(C1)cccc2Nc3ccccc3-c4nnn[nH]4
InChI
1S/C17H17N5/c1-2-8-13-12(6-1)7-5-11-15(13)18-16-10-4-3-9-14(16)17-19-21-22-20-17/h3-5,7,9-11,18H,1-2,6,8H2,(H,19,20,21,22)
InChI key
YYNRZIFBTOUICE-UHFFFAOYSA-N
General description
BL-1249 is a non-steroid anti-inflammatory drug and an inhibitor of the cyclooxygenase (COX) enzyme.
Application
BL-1249 has been used:
- as an activator of mechano-gated K2P channel in contracted mouse ileum and colon tissues
- as a TWIK related potassium channel (TREK2) modulator and in U-2 OS osteosarcoma cell line
- as a TREK1 and TREK2 activator in mice.
Biochem/physiol Actions
BL-1249 also activates TWIK related potassium channel 2 (TREK2). It interacts with K2P channel at the negatively charged activator site and modulates channel opening.
BL-1249 is a potassium TREK-1 channel activator.
BL-1249 is a putative activator of potassium TREK-1 channel.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves