B2515
L-丁硫氨酸亚砜亚胺
≥97% (TLC)
别名:
L-BSO
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关于此项目
经验公式（希尔记法）:
C8H18N2O3S
CAS Number:
分子量:
222.31
Beilstein:
2367136
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
生物来源
synthetic (organic)
质量水平
方案
≥97% (TLC)
表单
powder
mp
224-226 °C
溶解性
water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
运输
wet ice
储存温度
−20°C
SMILES字符串
CCCCS(=N)(=O)CC[C@H](N)C(O)=O
InChI
1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1
InChI key
KJQFBVYMGADDTQ-CVSPRKDYSA-N
基因信息
human ... GCLC(2729), GCLM(2730)
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应用
L丁硫氨酸-亚砜亚胺已用作：
- 选择性激活剂，以诱导大鼠凋亡细胞的铁死亡
- γ谷氨酰半胱氨酸合成酶抑制剂，以研究其对小黑麦和大麦小孢子胚胎发生（ME）诱导活力和效果的影响
- 谷胱甘肽合成阻断剂，以研究其在小鼠肺泡巨噬细胞中金诺芬（AFN）介导的白介素-1β表达的影响
用于诱导实验性谷胱甘肽缺乏，以研究谷胱甘肽在细胞过程中的作用。
生化/生理作用
通过抑制谷胱甘肽生物合成中的关键酶γ-谷氨酰半胱氨酸合成酶，进而阻断对化疗的细胞抵抗性。用于诱导实验性谷胱甘肽缺乏，以研究谷胱甘肽在细胞过程中的作用。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Zeyu Cao et al.
Scientific reports, 7(1), 16278-16278 (2017-11-28)
Enterovirus 71 (EV71) is a key pathogen of hand, foot and mouth disease (HFMD) in children under 6 years of age. The antiviral potency of antioxidant isochlorogenic acid C (ICAC) extracted from foods was evaluated in cellular and animal models.
Kondareddy Cherukula et al.
Theranostics, 9(9), 2505-2525 (2019-05-28)
The delivery of therapeutics into tumors remains a challenge in nanoparticle-mediated drug delivery. However, effective therapies such as photothermal therapy (PTT) are limited by quick systemic clearance and non-specific biodistribution. Anti-tumor strategies tailored to accommodate both tumor accumulation/retention and cellular
Hannes M Findeisen et al.
PloS one, 6(4), e18532-e18532 (2011-05-03)
Aging constitutes a major independent risk factor for the development of type 2 diabetes and is accompanied by insulin resistance and adipose tissue dysfunction. One of the most important factors implicitly linked to aging and age-related chronic diseases is the
Ajeya Nandi et al.
Immunology letters, 190, 93-107 (2017-07-25)
Macrophages are remarkably versatile in their ability to recognize and respond to a wide range of stimuli by expressing a variety of surface and intracellular receptors and triggering multiple signal transduction pathways. The onset of microbial infection is primarily determined
Tatjana Bosnjak et al.
Basic & clinical pharmacology & toxicology, 125(2), 89-99 (2019-03-28)
Proton pump inhibitors (PPIs) are prodrugs used in the treatment of peptic ulcer diseases. Once activated by acidic pH, the PPIs subsequently inhibit the secretion of gastric acid by covalently forming disulphide bonds with the SH groups of the parietal
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