B2515
L-丁硫氨酸亚砜亚胺
synthetic (organic), ≥97% (TLC), γ-glutamylcysteine synthetase inhibitor, powder
别名:
L-BSO
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关于此项目
经验公式（希尔记法）:
C8H18N2O3S
化学文摘社编号:
分子量:
222.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Beilstein/REAXYS Number:
2367136
产品名称
L-丁硫氨酸亚砜亚胺, ≥97% (TLC)
InChI
1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1
SMILES string
CCCCS(=N)(=O)CC[C@H](N)C(O)=O
InChI key
KJQFBVYMGADDTQ-CVSPRKDYSA-N
biological source
synthetic (organic)
assay
≥97% (TLC)
form
powder
mp
224-226 °C
solubility
water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
shipped in
wet ice
storage temp.
−20°C
Quality Level
Gene Information
human ... GCLC(2729), GCLM(2730)
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Application
L丁硫氨酸-亚砜亚胺已用作：
- 选择性激活剂，以诱导大鼠凋亡细胞的铁死亡
- γ谷氨酰半胱氨酸合成酶抑制剂，以研究其对小黑麦和大麦小孢子胚胎发生（ME）诱导活力和效果的影响
- 谷胱甘肽合成阻断剂，以研究其在小鼠肺泡巨噬细胞中金诺芬（AFN）介导的白介素-1β表达的影响
用于诱导实验性谷胱甘肽缺乏，以研究谷胱甘肽在细胞过程中的作用。
Biochem/physiol Actions
通过抑制谷胱甘肽生物合成中的关键酶γ-谷氨酰半胱氨酸合成酶，进而阻断对化疗的细胞抵抗性。用于诱导实验性谷胱甘肽缺乏，以研究谷胱甘肽在细胞过程中的作用。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
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