B2517
6-生物蝶呤
≥97%
别名:
(1’R,2’S)-生物蝶呤, 2-氨基-4-羟基-6-(1,2-二羟基丙基)蝶啶, L-赤-6-(1,2-二羟基丙基)蝶蛉
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关于此项目
经验公式（希尔记法）:
C9H11N5O3
化学文摘社编号:
分子量:
237.22
UNSPSC Code:
41106305
NACRES:
NA.51
PubChem Substance ID:
EC Number:
244-807-8
Beilstein/REAXYS Number:
87860
MDL number:
产品名称
6-生物蝶呤, ≥97%
InChI
1S/C9H11N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h2-3,6,15-16H,1H3,(H3,10,11,13,14,17)/t3-,6-/m0/s1
SMILES string
C[C@H](O)[C@H](O)c1cnc2NC(N)=NC(=O)c2n1
InChI key
LHQIJBMDNUYRAM-DZSWIPIPSA-N
biological source
synthetic
assay
≥97%
form
powder
solubility
1 M NaOH: soluble-10 mg/mL, clear, colorless to light greenish-yellow
storage temp.
2-8°C
Quality Level
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Application
6-生物蝶呤是一种来自黑色素生成调节辅因子(6R)5,6,7,8四氢生物蝶呤(6-BH4)的氧化产物。在体外，6-生物蝶呤对黑色素细胞存在细胞毒性。然而，6-生物喋呤在体内可通过q-BH2快速依序还原成6-GH4。最近的研究表明，6-生物喋呤和其他蝶蛉类物质可能是一种重要的癌症非侵入性生物标记物。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Scientific reports, 7(1), 9472-9472 (2017-08-27)
Intracellular pathogens belonging to the genus Leishmania have developed effective strategies that enable them to survive within host immune cells. Immunostimulatory compounds that counteract such immunological escape mechanisms represent promising treatment options for diseases. Here, we demonstrate that a lipopeptidephosphoglycan
Abulizi Abudukadier et al.
Diabetes, 62(9), 3033-3043 (2013-05-08)
Endothelial nitric oxide synthase (eNOS) dysfunction induces insulin resistance and glucose intolerance. Tetrahydrobiopterin (BH4) is an essential cofactor of eNOS that regulates eNOS activity. In the diabetic state, BH4 is oxidized to 7,8-dihydrobiopterin, which leads to eNOS dysfunction owing to
Jarl Underhaug et al.
Current topics in medicinal chemistry, 12(22), 2534-2545 (2013-01-24)
Phenylketonuria (PKU) is a loss-of-function inborn error of metabolism. As many other inherited diseases the main pathologic mechanism in PKU is an enhanced tendency of the mutant phenylalanine hydroxylase (PAH) to misfold and undergo ubiquitin-dependent degradation. Recent alternative approaches with
Sanjeewa Gamagedara et al.
Clinica chimica acta; international journal of clinical chemistry, 412(1-2), 120-128 (2010-09-28)
Biomarkers are good potential tools for early cancer diagnosis. Here we have analyzed eight different pteridines in the urine samples of cancer patients and compared them with samples from healthy subjects. Pteridines are important cofactors in the process of cell
Adrien Weingärtner et al.
PloS one, 7(8), e42070-e42070 (2012-08-08)
The protozoan parasite Leishmania is an intracellular pathogen infecting and replicating inside vertebrate host macrophages. A recent model suggests that promastigote and amastigote forms of the parasite mimic mammalian apoptotic cells by exposing phosphatidylserine (PS) at the cell surface to
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