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B2640

DL-丁硫氨酸-(S,R)-亚砜亚胺

Name: <SC>DL</SC>-丁硫氨酸-(<I>S</I>,<I>R</I>)-亚砜亚胺
Brand: SIGMA

synthetic (organic), ≥98% (TLC), γ-glutamylcysteine synthetase inhibitor, powder

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关于此项目

线性分子式:

CH₃(CH₂)₃S(O)(=NH)CH₂CH₂CH(NH₂)CO₂H

化学文摘社编号:

5072-26-4

分子量:

222.31

UNSPSC Code:

12161501

PubChem Substance ID:

24278264

NACRES:

NA.77

MDL number:

MFCD00070309

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

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产品名称

DL-丁硫氨酸-(S,R)-亚砜亚胺,

biological source

synthetic (organic)

Quality Level

200

assay

≥98% (TLC)

form

powder

mp

215 °C (dec.) (lit.)

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless to yellow

storage temp.

2-8°C

SMILES string

CCCCS(=N)(=O)CCC(N)C(O)=O

InChI

1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)

InChI key

KJQFBVYMGADDTQ-UHFFFAOYSA-N

General description

DL-丁硫氨酸-SR-亚砜亚胺（BSO）是一种氨基酸类似物，可作为γ-谷氨酰半胱氨酸合成酶的抑制剂。BSO可提高克氏锥虫对抗寄生虫药物（如硝呋莫司或苄硝唑）的敏感性。

Application

DL-丁硫氨酸-(S,R)-亚砜亚胺已用于：

诱发椋鸟的氧化应激
耗竭出生两天的大鼠幼崽中的脉络膜谷胱甘肽(GSH)
检测其对克氏锥虫(T. cruzi)的γ-谷氨酰半胱氨酸合成酶和 trypanothione（一种锥虫谷胱甘肽）合成酶(TryS)的抑制作用

DL-丁硫氨酸-(S,R)-亚砜亚胺已被用于消耗视网膜神经节细胞 5 (RGC-5) 细胞系中的细胞谷胱甘肽水平。

Biochem/physiol Actions

耗竭细胞谷胱甘肽，下调 GST 级别。

Features and Benefits

这种化合物是 ADME 毒性研究的特色产品。点击此处发现更多特色 ADME 毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000517274

0000498015

0000443005

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全球贸易项目编号

货号	GTIN
B2640-500MG	04061833427002
B2640-1G	04061833426999
B2640-5G	04061833427019

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