B2643
生物素酰胺己酸 N-羟基琥珀酰亚胺酯
≥98% (TLC), powder
别名:
(+)-生物素氨基己酸酯 N-羟基琥珀酰亚胺酯, 6-己酸琥珀酰亚胺酯, N-(+)-生物素-6-氨基己酸 N-琥珀酰亚胺酯, N-(+)-生物素-6-氨基己酸 NHS 酯, N-琥珀酰亚胺基 N-生物素基-6-氨基己酸酯
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关于此项目
经验公式（希尔记法）:
C20H30N4O6S
化学文摘社编号:
分子量:
454.54
UNSPSC Code:
12352203
NACRES:
NA.46
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
3577403
产品名称
生物素酰胺己酸 N-羟基琥珀酰亚胺酯, ≥98% (TLC), powder
InChI
1S/C20H30N4O6S/c25-15(7-4-3-6-14-19-13(12-31-14)22-20(29)23-19)21-11-5-1-2-8-18(28)30-24-16(26)9-10-17(24)27/h13-14,19H,1-12H2,(H,21,25)(H2,22,23,29)/t13-,14-,19-/m0/s1
SMILES string
[H][C@]12CS[C@@H](CCCCC(=O)NCCCCCC(=O)ON3C(=O)CCC3=O)[C@@]1([H])NC(=O)N2
InChI key
UVGHPGOONBRLCX-NJSLBKSFSA-N
assay
≥98% (TLC)
form
powder
solubility
H2O: ≤2 mg/mL (with sonication)
DMF: 50 mg/mL (Stable up to 2 months in dry DMF.)
storage temp.
−20°C
Quality Level
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Application
生物素氨基己酸N-羟基琥珀酰亚胺酯已用于抗体的生物素化。
Biochem/physiol Actions
生物素是一种广泛应用于生物化学领域的标签，与亲和素高度亲和。当将生物素（小分子）偶联到生物聚合物（大分子）时，需要一个间隔链来减少空间位阻。生物素氨基己酸 N-羟基琥珀酰亚胺酯含有一个7原子间隔基和N-琥珀酰亚胺离去基。它能与pH值在6.5-8.5范围内的伯胺反应。这种生物素化试剂含有氨基丙基间隔体，因此可以减少亲和素与某些生物素化化合物结合时的空间位阻。
Disclaimer
除非我们的产品目录或产品随附的其他公司文件中另有说明，否则我们的产品仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途或任何类型的人类或动物消费或应用。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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The Biochemical journal, 401(2), 475-483 (2006-10-05)
PrPSc [abnormal disease-specific conformation of PrP (prion-related protein)] accumulates in prion-affected individuals in the form of amorphous aggregates. Limited proteolysis of PrPSc results in a protease-resistant core of PrPSc of molecular mass of 27-30 kDa (PrP27-30). Aggregated forms of PrP
C Hughes et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 3(4), 623-630 (2001-04-26)
Three strategies have been designed to concentrate infectious retroviral vectors from the supernatants of human- (HT1080) and murine- (NIH 3T3) based packaging cells. Streptavidin-conjugated paramagnetic particles in conjunction with (i) antibodies directed against murine fibronectin, (ii) biotinylated lectins, or (iii)
C Pellat-Deceunynck et al.
Blood, 84(8), 2597-2603 (1994-10-15)
CD28 and CD40 are important activation pathways for T and B lymphocytes, respectively. The aim of this study was to determine the phenotype of plasma cells (PCs) and the expression of these two molecules, CD28 and CD40. Therefore, we have
Vincent H B Ho et al.
Ultrasound in medicine & biology, 37(1), 169-175 (2010-11-19)
Magnetite (Fe(3)O(4)) nanoparticle agglomerates have been shown to enhance the degree of inertial cavitation induced by high-intensity focused ultrasound (HIFU). To investigate the effect of these particles on the destruction of tumor spheroids using HIFU, HeLa spheroids were insonated in
Heike M Pirner et al.
The Journal of biological chemistry, 281(18), 12381-12389 (2006-03-15)
Biotin is a water-soluble vitamin that functions as a prosthetic group in carboxylation reactions. In addition to its role as a cofactor, biotin has multiple roles in gene regulation. We analyzed biotin effects on gene expression in the yeast Saccharomyces
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