B2682
Boc-Asp(OMe)-fluoromethyl ketone
≥90% (TLC), solid
别名:
Boc-D-FMK
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关于此项目
经验公式（希尔记法）:
C11H18NO5F
化学文摘社编号:
分子量:
263.26
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
InChI
1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)/t7-/m0/s1
SMILES string
COC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)CF
InChI key
MXOOUCRHWJYCAL-ZETCQYMHSA-N
assay
≥90% (TLC)
form
solid
solubility
DMF: soluble
storage temp.
−20°C
Quality Level
Application
Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells , as a component of the transplantation medium for the transplantation of human embryonic stem cells (ESC)-derived medial ganglionic eminence (MGE) cells into hippocampus of mice , as a protease inhibitor to study its effects on cell death in parasites .
Biochem/physiol Actions
Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) permits cell permeability. It is a caspase inhibitor and suppresses apoptosis induced by various kinds of stimuli. Boc-D-fmk poorly inhibits caspases-2, -5, -6 and -10.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Caspase-independent cell death induced by anti-CD2 or staurosporine in activated human peripheral T lymphocytes
Deas O, et al.
Journal of immunology (Baltimore, Md. : 1950), 161(7), 3375-3383 (1998)
Y M Chan et al.
Neuroreport, 12(3), 541-545 (2001-03-10)
Following ventral root avulsion in neonatal animals, the degeneration of spinal motoneurons occurs by an apoptotic-like morphological pathway. In adult animals, however, the mechanism of degeneration of injured motoneurons is still controversial. Because caspases are important mediators of apoptosis, we
Broad-spectrum caspase inhibitors: from myth to reality?
Chauvier D, et al.
Cell Death and Differentiation, 14(2), 387-391 (2007)
Lactate dehydrogenase leakage as a marker for apoptotic cell degradation induced by influenza virus infection in human fetal membrane cells
Uchide N, et al.
Intervirology, 52(3), 164-173 (2009)
Differentiation of human pluripotent stem cells into Medial Ganglionic Eminence vs. Caudal Ganglionic Eminence cells
Ahn S, et al.
Methods, 101(3), 103-112 (2016)
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