Boc-Asp(OMe)-fluoromethyl ketone

Name: Boc-Asp(OMe)-fluoromethyl ketone
Brand: SIGMA

≥90% (TLC), solid

别名:

Boc-D-FMK

登录查看公司和协议定价

所有图片(1)

About This Item

经验公式（希尔记法）:

C₁₁H₁₈NO₅F

CAS Number:

187389-53-3

分子量:

263.26

MDL编号:

MFCD03453073

UNSPSC代码:

12352209

PubChem化学物质编号:

329773206

NACRES:

NA.77

方案

≥90% (TLC)

表单

solid

溶解性

DMF: soluble

储存温度

−20°C

SMILES字符串

COC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)CF

InChI

1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)/t7-/m0/s1

InChI key

MXOOUCRHWJYCAL-ZETCQYMHSA-N

应用

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells , as a component of the transplantation medium for the transplantation of human embryonic stem cells (ESC)-derived medial ganglionic eminence (MGE) cells into hippocampus of mice , as a protease inhibitor to study its effects on cell death in parasites .

生化/生理作用

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) permits cell permeability. It is a caspase inhibitor and suppresses apoptosis induced by various kinds of stimuli. Boc-D-fmk poorly inhibits caspases-2, -5, -6 and -10.