B2682
Boc-Asp(OMe)-fluoromethyl ketone
≥90% (TLC), solid
别名:
Boc-D-FMK
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关于此项目
经验公式（希尔记法）:
C11H18NO5F
化学文摘社编号:
分子量:
263.26
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥90% (TLC)
表单
solid
溶解性
DMF: soluble
储存温度
−20°C
SMILES字符串
COC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)CF
InChI
1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)/t7-/m0/s1
InChI key
MXOOUCRHWJYCAL-ZETCQYMHSA-N
相关类别
应用
Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells , as a component of the transplantation medium for the transplantation of human embryonic stem cells (ESC)-derived medial ganglionic eminence (MGE) cells into hippocampus of mice , as a protease inhibitor to study its effects on cell death in parasites .
生化/生理作用
Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) permits cell permeability. It is a caspase inhibitor and suppresses apoptosis induced by various kinds of stimuli. Boc-D-fmk poorly inhibits caspases-2, -5, -6 and -10.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Broad-spectrum caspase inhibitors: from myth to reality?
Chauvier D, et al.
Cell Death and Differentiation, 14(2), 387-391 (2007)
Y M Chan et al.
Neuroreport, 12(3), 541-545 (2001-03-10)
Following ventral root avulsion in neonatal animals, the degeneration of spinal motoneurons occurs by an apoptotic-like morphological pathway. In adult animals, however, the mechanism of degeneration of injured motoneurons is still controversial. Because caspases are important mediators of apoptosis, we
Caspase-independent cell death induced by anti-CD2 or staurosporine in activated human peripheral T lymphocytes
Deas O, et al.
Journal of immunology (Baltimore, Md. : 1950), 161(7), 3375-3383 (1998)
Qiruo Gao et al.
Cell biochemistry and biophysics, 70(1), 461-465 (2014-05-06)
Adiponectin, an adipose tissue-derived hormone, has been studied intensively for the past decade because of its anti-inflammatory, anti-atherogenic, and anti-diabetic properties. Recent advances suggest that adiponectin also plays an important role in the development and progression of various cancers. Accumulating
Differentiation of human pluripotent stem cells into Medial Ganglionic Eminence vs. Caudal Ganglionic Eminence cells
Ahn S, et al.
Methods, 101(3), 103-112 (2016)
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