B2682
Boc-Asp(OMe)-fluoromethyl ketone
≥90% (TLC), solid
别名:
Boc-D-FMK
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关于此项目
经验公式（希尔记法）:
C11H18NO5F
化学文摘社编号:
分子量:
263.26
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
InChI
1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)/t7-/m0/s1
SMILES string
COC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)CF
InChI key
MXOOUCRHWJYCAL-ZETCQYMHSA-N
assay
≥90% (TLC)
form
solid
solubility
DMF: soluble
storage temp.
−20°C
Quality Level
Application
Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells , as a component of the transplantation medium for the transplantation of human embryonic stem cells (ESC)-derived medial ganglionic eminence (MGE) cells into hippocampus of mice , as a protease inhibitor to study its effects on cell death in parasites .
Biochem/physiol Actions
Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) permits cell permeability. It is a caspase inhibitor and suppresses apoptosis induced by various kinds of stimuli. Boc-D-fmk poorly inhibits caspases-2, -5, -6 and -10.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Differentiation of human pluripotent stem cells into Medial Ganglionic Eminence vs. Caudal Ganglionic Eminence cells
Ahn S, et al.
Methods, 101(3), 103-112 (2016)
Heat-induced programmed cell death in Leishmania infantum is reverted by Bcl-X L expression
Alzate JF, et al.
Apoptosis, 11(2), 161-171 (2006)
Lactate dehydrogenase leakage as a marker for apoptotic cell degradation induced by influenza virus infection in human fetal membrane cells
Uchide N, et al.
Intervirology, 52(3), 164-173 (2009)
Qiruo Gao et al.
Cell biochemistry and biophysics, 70(1), 461-465 (2014-05-06)
Adiponectin, an adipose tissue-derived hormone, has been studied intensively for the past decade because of its anti-inflammatory, anti-atherogenic, and anti-diabetic properties. Recent advances suggest that adiponectin also plays an important role in the development and progression of various cancers. Accumulating
Y M Chan et al.
Neuroreport, 12(3), 541-545 (2001-03-10)
Following ventral root avulsion in neonatal animals, the degeneration of spinal motoneurons occurs by an apoptotic-like morphological pathway. In adult animals, however, the mechanism of degeneration of injured motoneurons is still controversial. Because caspases are important mediators of apoptosis, we
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