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B2805

BMP6, human

Name: BMP6, human
Brand: SIGMA

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

别名:

Bone Morphogenetic Protein 6 human, BMP-6

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关于此项目

UNSPSC Code:

12352202

NACRES:

NA.32

MDL number:

MFCD02097809

Biological source:

human

Recombinant:

expressed in NSO cells

Assay:

>95% (SDS-PAGE)

Form:

lyophilized powder

Mol wt:

30–38 kDa

Impurities:

endotoxin, tested

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属性

产品名称

Bone Morphogenetic Protein 6 human, >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

biological source

human

Quality Level

100

recombinant

expressed in NSO cells

assay

>95% (SDS-PAGE)

form

lyophilized powder

potency

0.05-0.15 μg/mL ED₅₀

mol wt

30–38 kDa

packaging

pkg of 20 μg

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P22004

storage temp.

−20°C

Gene Information

human ... BMP6(654)

说明

Biochem/physiol Actions

Cellular responses to BMP-6 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. Mature human and murine BMP-6 demonstrates 96% homology.

Physical form

Lyophilized from 200 ul 0.2 μm filtered solution in 40% acetonitrile, 0.1% trifluoroacetic acid containing 50ug bovine serum albumin per 1 ug as a carrier protein.

Analysis Note

The biological activity is measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells.

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wgk

WGK 3

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Bone morphogenetic proteins and their receptors: potential functions in the brain.

Ebendal, T., et al

The Journal of Neuroscience, 51, 139-146 (1998)

Enhanced expression of BMP6 inhibits hepatic fibrosis in non-alcoholic fatty liver disease.

Stephanie Arndt et al.

Gut, 64(6), 973-981 (2014-07-12)

Bone morphogenetic protein 6 (BMP6) has been identified as crucial regulator of iron homeostasis. However, its further role in liver pathology including non-alcoholic fatty liver disease (NAFLD) and its advanced form non-alcoholic steatohepatitis (NASH) is elusive. The aim of this

Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload.

Christine E McLaren et al.

Hepatology (Baltimore, Md.), 62(2), 429-439 (2015-01-22)

To identify polymorphisms associated with variability of iron overload severity in HFE-associated hemochromatosis, we performed exome sequencing of DNA from 35 male HFE C282Y homozygotes with either markedly increased iron stores (n = 22; cases) or with normal or mildly increased iron

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全球贸易项目编号

货号	GTIN
B2805-20UG	04061833427125