跳转至内容
Merck
CN

B3259

缓激肽 乙酸盐

≥98% (HPLC), Ca2+-dependent nitric oxide synthetase activator, powder

登录 查看组织和合同定价。

选择尺寸

关于此项目

经验公式（希尔记法）:
C50H73N15O11 · xC2H4O2
化学文摘社编号:
6846-03-3
分子量:
1060.21 (free base basis)
MDL number:
MFCD00076258
UNSPSC Code:
12352106
EC Number:
227-781-2
NACRES:
NA.32
Assay:
≥98% (HPLC)
Form:
powder
Solubility:
0.1 M acetic acid: 25 mg/mL, clear, colorless

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

缓激肽 乙酸盐, powder, ≥98% (HPLC)

SMILES string

N2([C@@H](CCC2)C(=O)NCC(=O)N[C@@H](Cc5ccccc5)C(=O)N[C@@H](CO)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N

InChI key

QXZGBUJJYSLZLT-FDISYFBBSA-N

InChI

1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

0.1 M acetic acid: 25 mg/mL, clear, colorless

UniProt accession no.

P01042

storage temp.

−20°C

Quality Level

100

Gene Information

human ... KNG1 (includes EG:3827)

正在寻找类似产品? 访问 产品对比指南

相关类别

Application

Bradykinin acetate salt has been used:
  • to stimulate the contraction of guinea pig ileum
  • as a contractile agent in fibroblasts
  • In the stimulation of endothelium of human subcutaneous artery
  • To evoke Ca2+ signals in neuroblastoma-glioma hybrid cell line, NG108-15

Biochem/physiol Actions

激活痛觉受体；引起平滑肌收缩；激活 Ca2+ 依赖性一氧化氮合成酶；增加毛细血管通透性。
缓激肽是一种促炎肽，通过 G-蛋白质偶联受体进行作用。它活化鞘脂类的代谢。经缓激肽处理的成纤维细胞的神经酰胺分泌量会有快速而重大的增长，随后鞘氨醇含量也会短暂上升。这种肽也会通过使中性糖脂快速移动来增加细胞的神经酰胺含量。缓激肽在体液和电解质平衡的调节、平滑肌收缩、血管舒张和毛细血管通透性方面都发挥着重要的作用。缓激肽增效剂本身不具有缓激肽活性，但能增强缓激肽的活性。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN2570
BCCL3438
BCCK2555
BCCH8393
BCCG0917

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Vasomotor dysfunction in human subcutaneous arteries exposed ex vivo to food-grade titanium dioxide
Jensen DM, et al.
Food And Chemical Toxicology, 120, 321-327 (2018)
Haptotaxis is cell type specific and limited by substrate adhesiveness
Wen JH, et al.
Cellular and Molecular Bioengineering, 8(4), 530-542 (2015)
C L Boyajian et al.
The Journal of biological chemistry, 266(8), 4995-5003 (1991-03-15)
The modulation of neuronal adenylylcyclase by Ca2+, acting via calmodulin, is a long-established example of a positive interaction between the Ca2(+)-mobilizing and cAMP-generating systems. In the present study, concentrations of Ca2+ that stimulate brain adenylylcyclase inhibit the adenylylcyclase of NCB-20
Henriette Farkas
Expert opinion on pharmacotherapy, 14(5), 571-586 (2013-03-14)
Bradykinin-mediated angioedema is characterized by subcutaneous and/or submucosal edema formation without wheals and pruritus. It is linked to bradykinin-enhanced vascular permeability and, therefore, it does not respond to conventional measures, but requires specific therapy. This summary briefly reviews the different
Louis Potier et al.
The Journal of pharmacology and experimental therapeutics, 346(1), 23-30 (2013-04-18)
Cardiac ischemia is a leading cause of death, especially in diabetic patients. The diabetic ischemic heart is resistant experimentally to established cardioprotective treatments. New pharmacological approaches to cardiac protection are warranted. The kallikrein-kinin system is involved in myocardial protection in
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持