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Merck
CN

B3303

布舍瑞林 乙酸盐

≥90% (HPLC)

别名:

des-Gly10-[D-Ser[t-Bu]6]-LH-RH ethylamide acetate salt, pGlu-His-Trp-Ser-Tyr-D-Ser(t-Bu)-Leu-Arg-Pro-NHEt acetate salt

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关于此项目

经验公式（希尔记法）:
C60H86N16O13 · C2H4O2
化学文摘社编号:
68630-75-1
分子量:
1299.48
UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
MFCD00941414
Form:
powder
Assay:
≥90% (HPLC)

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SMILES string

[nH]1cncc1C[C@H](NC(=O)[C@H]6NC(=O)CC6)C(=O)N[C@@H](Cc4c5c([nH]c4)cccc5)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc3ccc(cc3)O)C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N2[C@@H](CCC2)C(=O)NCC.OC(=O)C

InChI

1S/C60H86N16O13.C2H4O2/c1-7-64-57(87)48-15-11-23-76(48)58(88)41(14-10-22-65-59(61)62)69-51(81)42(24-33(2)3)70-56(86)47(31-89-60(4,5)6)75-52(82)43(25-34-16-18-37(78)19-17-34)71-55(85)46(30-77)74-53(83)44(26-35-28-66-39-13-9-8-12-38(35)39)72-54(84)45(27-36-29-63-32-67-36)73-50(80)40-20-21-49(79)68-40;1-2(3)4/h8-9,12-13,16-19,28-29,32-33,40-48,66,77-78H,7,10-11,14-15,20-27,30-31H2,1-6H3,(H,63,67)(H,64,87)(H,68,79)(H,69,81)(H,70,86)(H,71,85)(H,72,84)(H,73,80)(H,74,83)(H,75,82)(H4,61,62,65);1H3,(H,3,4)/t40-,41-,42-,43-,44-,45-,46-,47+,48-;/m0./s1

InChI key

PYMDEDHDQYLBRT-DRIHCAFSSA-N

assay

≥90% (HPLC)

form

powder

UniProt accession no.

P12391

storage temp.

−20°C

Quality Level

200

Gene Information

rat ... Chrnb3(171131)

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Biochem/physiol Actions

Buserelin is an LH-RH agonist.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

hcodes

H302,H360

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCK3361
BCCF7047
BCBZ3987
BCBV1707
BCBD9630V

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Tom Pickles et al.
BJU international, 110(11 Pt B), E500-E507 (2012-05-09)
What's known on the subject? and What does the study add? Previous reports, with small numbers of patients, have described the problem of incomplete testosterone suppression (>1.1 or 1.7 nmol/L) with LHRH agonists. Various predisposing factors have been suggested: different
C M Kershaw-Young et al.
Reproduction, fertility, and development, 24(8), 1093-1097 (2012-09-07)
Ovulation in camelids is induced by an unidentified protein in the seminal plasma of the male termed 'ovulation-inducing factor'. This protein has been reported to be a 14-kDa protein under reducing conditions, which, when purified from seminal plasma, induces ovulation
S Zhao et al.
Gynecologic and obstetric investigation, 49(1), 52-56 (2000-01-12)
Gonadotropin-releasing hormone (GnRH) has been found to be expressed in ovaries of various species and to modulate cell differentiation in ovarian cells. GnRH agonists (GnRHa) are widely used in the stimulation protocols of assisted reproduction. In the present study, the
M M Herlihy et al.
Journal of dairy science, 95(2), 743-754 (2012-01-28)
Lactating dairy cows (n=57) ≥45 d postpartum at first service were enrolled in a randomized complete block design study to evaluate treatments to synchronize estrus and ovulation. At 10 d before artificial insemination (AI), animals were randomly assigned to 1
Elin Sand et al.
Cell and tissue research, 351(3), 521-534 (2012-12-21)
Gonadotropin-releasing hormone (GnRH) analogs are given to women undergoing in vitro fertilization. Case reports describing the development of chronic intestinal pseudo-obstruction and auto-antibodies against GnRH after such treatment suggest a strong association between intestinal dysfunction and GnRH analogs. No experimental
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