Merck
CN
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文件

B3306

Sigma-Aldrich

Bisindolylmaleimide IV

≥98% (TLC), solid

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别名:
Ro 31-6233
经验公式（希尔记法）:
C20H13N3O2
CAS号:
119139-23-0
分子量:
327.34
MDL编号:
MFCD00236432
PubChem化学物质编号:
24891709
NACRES:
NA.77

生物来源

synthetic (organic)

质量水平

200

检测方案

≥98% (TLC)

形式

solid

颜色

dark red

溶解性

DMSO: soluble
methanol: soluble

储存温度

−20°C

SMILES string

O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c4c[nH]c5ccccc45

InChI

1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)

InChI key

DQYBRTASHMYDJG-UHFFFAOYSA-N

Gene Information

human ... CDK2(1017) , EGFR(1956)
rat ... Prkca(24680)

生化/生理作用

Bisindolylmaleimides (BIM) comprises a group of 11 compounds from BIM-I to BIM-XI. BIMs act as an inhibitor of protein kinase C (PKC). They are derived from staurosporine. BIM IX due to its proapoptotic functionality could be useful in targeting tumor proliferation.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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