B3811
B-9430 trifluoroacetate salt
≥98% (HPLC)
别名:
D-Arg-Arg-Pro-Hyp-Gly-Igl-Ser-D-Igl-Oic-Arg trifluoroacetate salt, D-Arg-[Hyp3, Igl5, D-Igl7, Oic8]-Bradykinin trifluoroacetate salt
方案
≥98% (HPLC)
表单
solid
储存条件
protect from light
under inert gas
溶解性
H2O: ≥2 mg/mL
运输
wet ice
储存温度
−20°C
Amino Acid Sequence
Arg-Arg-Pro-Hyp-Gly-Igl-Ser-Igl-Oic-Arg
生化/生理作用
B-9430 was developed by Gera at the Stewart laboratory1 and is a stable, potent, and long lasting Bradykinin (BK) antagonist, a candidate anti-inflammatory drug. B-9430 shows potency at bradykinin B2 (pA2 = 8.6) and B1 receptors (pA2 = 7.3). Bradykinin is an important growth factor for small-cell lung cancer (SCLC) and prostate cancer (PC). BK receptors are expressed on almost all lung cancer cell lines and on many PC cells. B-9430 is very resistant to kinases and thus shows a very long action in vivo. This peptide is unique among bradykinin antagonists in that it is active after oral administration.
Stable, potent, and long lasting Bradykinin (BK) antagonist, which shows high BK antagonism on both B-1 and B-2 receptors.
免责声明
Product is air and light sensitive. Store in the dark.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
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