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Merck
CN

B4186

丁酰胆碱酯酶 来源于人类血清

vial of ≥4 units

别名:

假性胆碱酯酶, 胆碱酯酶，丁酰基, 酰基胆碱酰基水解酶

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化学文摘社编号:
9001-08-5
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-579-2
MDL number:
MFCD00081455
EC 号:
3.1.1.8 (BRENDA, IUBMB)

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产品名称

丁酰胆碱酯酶 来源于人类血清, vial of ≥4 units

form

powder

specific activity

≥50 units/mg protein

packaging

vial of ≥4 units

UniProt accession no.

P06276

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... BCHE(590)

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Analysis Note

经单独供体测试的起始材料，并经发现对HIV I和II抗体、乙型肝炎表面抗原和丙型肝炎抗体呈阴性。

Application

人丁酰胆碱酯酶已被用于研究其作为阿尔茨海默′病 (AD) 体内病理特征调节剂的作用。
来自西格玛的BchE已被用于通过各种测试化合物测定丁酰胆碱酯酶抑制活性。

Biochem/physiol Actions

丁酰胆碱酯酶（BChE）是一种丝氨酸水解酶，其与乙酰胆碱酯酶（AchE）具有显著的结构相似性，但具有不同的底物和抑制剂特异性。 它存在于脊椎动物的血清、造血细胞、肝脏、肺脏、心脏和中枢神经系统中。BChE可催化胆碱的大型酯，如丁酰胆碱和苯甲酰胆碱。BChE活性的选择性抑制可用于有机磷酸酯的检测。BchE可用于治疗有机磷酸酯毒性。它是阿尔茨海默′病 (AD) 治疗中的关键靶点。
丁酰胆碱酯酶（BChE）是一种丝氨酸水解酶，其与乙酰胆碱酯酶（AchE）具有显著的结构相似性，但具有不同的底物和抑制剂特异性。BChE存在于脊椎动物的血清、造血细胞、肝脏、肺脏、心脏和中枢神经系统中。

Other Notes

在pH8.0,37℃条件下，一个单位每分钟可将1.0μmole丁酰胆碱水解为胆碱和丁酸盐。使用丁酰胆碱作为底物获得的活性是使用乙酰胆碱作为底物所获得的活性的约2.5倍。

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000501787
0000501787
0000456583
0000456583
0000458424

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What amount of enzyme is present in 1 vial of Product B4186, Butyrylcholinesterase from human serum?

    Each vial will contain at least 5 units. The vial content is given on the certificate of analysis of each lot. The vial may be substantially overpacked.

  6. How should Product B4186, Butyrylcholinesterase from human serum, be reconstituted?

    The enzyme can be reconstituted in 20 mM sodium phosphate buffer, pH 7.0, with 0.15 M sodium chloride.

  7. Are any buffer salts present in Product B4186, Butyrylcholinesterase from human serum?

    This product was lyophilized from 20 mM ammonium bicarbonate, which is a volatile buffer. So it would be expected to contain only traces of buffer salts.

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

The apolipoprotein E varepsilon4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase
Darreh-Shori T, et al.
Neurobiology of Aging, 32(7), 1236-1248 (2011)
Cholinesterases and engineered mutants for the detection of organophosphorus pesticide residues
Xu YL, et al.
Sensors, 18(12), 4281-4281 (2018)
The key role of butyrylcholinesterase during neurogenesis and neural disorders: an antisense-5? butyrylcholinesterase-DNA study
Mack A and Robitzki A
Progress in Neurobiology, 60(6), 607-628 (2000)
Huan-Huan Li et al.
Journal of enzyme inhibition and medicinal chemistry, 37(1), 2099-2111 (2022-07-29)
Novel scaffolds are expected to treat Alzheimer's disease, pyrazole-5-fluorosulfates were found as selective BuChE inhibitors. Compounds K1-K26 were assayed for ChE inhibitory activity, amongst them, compound K3 showed potent BuChE and hBuChE inhibition (IC50 = 0.79 μM and 6.59 μM). SAR analysis
A I Sacaan et al.
The Journal of pharmacology and experimental therapeutics, 280(1), 373-383 (1997-01-01)
Nicotine, the prototypical agonist for neuronal nicotinic acetylcholine receptors (NAChR), nonselectively activates NAChR limiting its use in elucidating the function of NAChR subtypes. SIB-1765F is a subtype selective NAChR agonist that displaces [3H]-nicotine binding with an IC50 of 4.6 nM
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