B4261
生物胞素
≥98% (TLC), suitable for drug transporter assays
别名:
Bct, Nε-(+)-生物素基-L-赖氨酸
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关于此项目
经验公式（希尔记法）:
C16H28N4O4S
化学文摘社编号:
分子量:
372.48
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Beilstein/REAXYS Number:
97197
产品名称
生物胞素, ≥98% (TLC)
InChI
1S/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1
SMILES string
[H][C@]12CS[C@@H](CCCCC(=O)NCCCC[C@H](N)C(O)=O)[C@@]1([H])NC(=O)N2
InChI key
BAQMYDQNMFBZNA-MNXVOIDGSA-N
assay
≥98% (TLC)
form
powder
optical activity
[α]20/D +53°, c = 1.05% in 0.1 M NaOH(lit.)
technique(s)
drug transporter assay: suitable
color
white to off-white
mp
~245 °C (dec.) (lit.)
storage temp.
−20°C
Quality Level
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Application
生物胞素被作为一种底物，研究生物素酶的特应性和动力学，用来检测生物素酶缺乏症，并且作为模型化合物研究细胞和组织的摄入机制。生物胞素用于标记神经元，中棘神经元和视神经。
Biochem/physiol Actions
生物胞素是赖氨酸和生物素加成。它被生物素酶水解，作用于肽链插入生物素或自由生物素。生物胞素可用作辅酶。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Jeanne T Paz et al.
Nature neuroscience, 16(1), 64-70 (2012-11-13)
Cerebrocortical injuries such as stroke are a major source of disability. Maladaptive consequences can result from post-injury local reorganization of cortical circuits. For example, epilepsy is a common sequela of cortical stroke, but the mechanisms responsible for seizures following cortical
Rui Tian et al.
Theranostics, 8(3), 735-745 (2018-01-19)
Purpose: Radionuclide therapy directed against tumors that express somatostatin receptors (SSTRs) has proven effective for the treatment of advanced, low- to intermediate-grade neuroendocrine tumors in the clinic. In clinical usage, somatostatin peptide-based analogs, labeled with therapeutic radionuclides, provide an overall
Vishwa Mohan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(32), 6233-6250 (2019-06-12)
Dendritic spines in the developing mammalian neocortex are initially overproduced and then eliminated during adolescence to achieve appropriate levels of excitation in mature networks. We show here that the L1 family cell adhesion molecule Close Homolog of L1 (CHL1) and
Dbx1 precursor cells are a source of inspiratory XII premotoneurons
Ann L Revill
eLife, 4, e12301-e12301 (2015)
Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson?s disease
William A
Neurobiology of Disease (2014)
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