B4313
(E/Z)-BCI 盐酸盐
≥98% (HPLC)
别名:
NSC 150117 盐酸盐, （e）-2-苄叉-3-（环己基氨基）-2,3-二氢-1H-茚-1-酮；3-（环己基氨基）-2,3-二氢-2-（苯基亚甲基）-1H-茚；2-苄叉-3-（环己基氨基）-1-茚酮 盐酸盐
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关于此项目
经验公式（希尔记法）:
C22H23NO · HCl
化学文摘社编号:
分子量:
353.89
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 10 mg/mL, clear
储存温度
2-8°C
SMILES字符串
Cl.O=C1C(=Cc2ccccc2)C(NC3CCCCC3)c4ccccc14
InChI
1S/C22H23NO.ClH/c24-22-19-14-8-7-13-18(19)21(23-17-11-5-2-6-12-17)20(22)15-16-9-3-1-4-10-16;/h1,3-4,7-10,13-15,17,21,23H,2,5-6,11-12H2;1H
InChI key
JPATUDRDKCLPTI-UHFFFAOYSA-N
相关类别
应用
(E/Z)-BCI盐酸盐已被用于：
- 评估Duox-H2O2-Dusp6 抑制信号途径在心脏再生中的作用
- 作为MKP-1 抑制剂考察MKP-1对蓓萨罗丁所致效应的作用
- 作为双特异性磷酸酶 6 (DUSP6) 抑制剂用于研究其对SKOV3细胞增生的作用
生化/生理作用
BCI是Dusp6的变构抑制剂，其可在磷酸酶结构域内起作用，以防止催化刺激由ERK2底物结合诱导的磷酸酶活性。由于Dusp6可充当FGF信号转导的反馈调节剂，因此BCI还可过度激活FGF信号转导。
（E/Z）-BCI盐酸盐是一种双特异性磷酸酶6（Dusp6）和Dusp1的抑制剂；可过度活化FGF信号转导。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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