B4436
Anti-53BP1 (C-terminal) antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-TP53BP1, Anti-p53 Binding Protein 1
产品名称
Anti-53BP1 (C-terminal) antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 345 kDa
species reactivity
mouse (predicted), rat (predicted), human
concentration
~1 mg/mL
technique(s)
immunoprecipitation (IP): 5-10 μg using HEK 293-T cell lysates
microarray: suitable
western blot: 2-4 μg/mL using U2OS total cell extracts
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TP53BP1(7158)
mouse ... Trp53bp1(27223)
rat ... Tp53bp1(296099)
Application
Anti-53BP1 (C-terminal) antibody produced in rabbit has been used in western blotting and immunoprecipitation
Biochem/physiol Actions
Tumor protein p53 binding protein (T153BP1) has a close link to ataxia-telangiectasia mutated (ATM)-regulated events. 53BP1 becomes phosphorylated by ATM in a DNA damage-dependent manner suggesting that it participates in propagating the ATM signaling to its downstream effectors. T153BP1 also plays a key role in DNA repair by mediating nonhomologous end-joining (NHEJ) near double stranded breaks (DSBs). Fusion of T153BP1 with platelet-derived growth factor receptor beta (PDGFRβ) is implicated in a type of myeloproliferative disorder accompanied with eosinophilia.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Tumor protein p53 binding protein (T153BP1) is mapped to human chromosome 15q15.3. It has methylated histone-binding module and tandem tudor domains.
Immunogen
synthetic peptide corresponding to amino acids 1955-1972 of human 53BP1, conjugated to KLH via an N-terminal added cysteine residue. This sequence is conserved in mouse, and differs from rat by one amino acid
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Michael T Perfetti et al.
ACS chemical biology, 10(4), 1072-1081 (2015-01-16)
Improving our understanding of the role of chromatin regulators in the initiation, development, and suppression of cancer and other devastating diseases is critical, as they are integral players in regulating DNA integrity and gene expression. Developing small molecule inhibitors for
p53-Binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with at (5; 15)(q33; q22) and an imatinib-responsive eosinophilic myeloproliferative disorder
Grand FH, et al.
Cancer Research, 64(20), 7216-7219 (2004)
Role of 53BP1 oligomerization in regulating double-strand break repair
Lottersberger F, et al.
Proceedings of the National Academy of Sciences of the USA, 110(6), 2146-2151 (2013)
Genomic landscape of liposarcoma
Kanojia D, et al.
Testing, 6(40), 42429-42429 (2015)
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair
Botuyan MV, et al.
Cell, 127(7), 1361-1373 (2006)
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