B4559
BRL 44408 maleate salt
≥98% (HPLC)
别名:
2-[2H-(1-Methyl-1,3-dihydroisoindole)methyl]-4,5-dihydroimidazole maleate salt
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关于此项目
经验公式（希尔记法）:
C17H21N3O4
化学文摘社编号:
分子量:
331.37
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: soluble 15 mg/mL, clear
originator
GlaxoSmithKline
SMILES string
OC(=O)\C=C/C(O)=O.CC1N(CC2=NCCN2)Cc3ccccc13
InChI
1S/C13H17N3.C4H4O4/c1-10-12-5-3-2-4-11(12)8-16(10)9-13-14-6-7-15-13;5-3(6)1-2-4(7)8/h2-5,10H,6-9H2,1H3,(H,14,15);1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key
DDIQGSUEJOOQQQ-BTJKTKAUSA-N
Biochem/physiol Actions
BRL 44408 maleate is a selective α2A-adrenoceptor antagonist.
Features and Benefits
This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Legal Information
Sold under agreement from GlaxoSmithKline
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Roberto T Sudo et al.
The journal of pain : official journal of the American Pain Society, 11(1), 71-78 (2009-10-27)
Finding new chemicals or adjuvants with analgesic effects in the central nervous system is clinically relevant due to the limited number of drugs with these properties. Here, we present PT-31, which is chemically related to 3-benzyl-imidazolidine, with an analgesic profile
Zoltán S Zádori et al.
Neurochemistry international, 51(5), 297-305 (2007-08-01)
The inhibitory effect of clonidine (non-selective alpha2-adrenoceptor agonist) and oxymetazoline (alpha2A-adrenoceptor selective agonist) was compared on basal and stimulated gastric motor activity (gastric tone and contractions) using the balloon method in the rat. It was shown that oxymetazoline (0.2-1.7 micromol/kg
Bruce Posner et al.
Analytical biochemistry, 365(2), 266-273 (2007-04-27)
Multiplexing of G protein-coupled receptors (GPCRs) in microarrays promises to increase the efficiency, reduce the costs, and improve the quality of high-throughput assays. However, this technology is still nascent and has not yet achieved the status of "high throughput" or
Junta Imaki et al.
Neuroscience letters, 454(2), 143-147 (2009-05-12)
We examined the effects of JP-1302 (a selective alpha2C antagonist), BRL-44408 (a selective alpha2A antagonist) and yohimbine (a non-selective alpha2 antagonist) on haloperidol-induced bradykinesia and catalepsy in mice to elucidate the role of alpha2 adrenoceptor subtypes in modifying extrapyramidal motor
Shawquia Young et al.
Basic & clinical pharmacology & toxicology, 107(2), 690-697 (2010-04-01)
Previously, we reported that antinociceptive synergism of a 5-HT(3)/alpha(2)-adrenoceptor ligand MD-354 (m-chlorophenylguanidine) and clonidine combination occurs, in part, through a 5-HT(3) receptor antagonist mechanism. In the present investigation, a possible role for alpha(2)-adrenoceptors was examined. Mechanistic studies using yohimbine (a
商品
Learn about alpha-2 adrenoceptor and its subtypes, mediated responses, and applications of agonists. Included is a list of available products and a comparison table.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| B4559-10MG | 04061833429785 |
| B4559-50MG | 04061833429808 |
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