B4559
BRL 44408 maleate salt
≥98% (HPLC)
别名:
2-[2H-(1-Methyl-1,3-dihydroisoindole)methyl]-4,5-dihydroimidazole maleate salt
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关于此项目
经验公式（希尔记法）:
C17H21N3O4
CAS Number:
分子量:
331.37
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
H2O: soluble 15 mg/mL, clear
创始人
GlaxoSmithKline
SMILES字符串
OC(=O)\C=C/C(O)=O.CC1N(CC2=NCCN2)Cc3ccccc13
InChI
1S/C13H17N3.C4H4O4/c1-10-12-5-3-2-4-11(12)8-16(10)9-13-14-6-7-15-13;5-3(6)1-2-4(7)8/h2-5,10H,6-9H2,1H3,(H,14,15);1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key
DDIQGSUEJOOQQQ-BTJKTKAUSA-N
生化/生理作用
BRL 44408 maleate is a selective α2A-adrenoceptor antagonist.
特点和优势
This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
法律信息
Sold under agreement from GlaxoSmithKline
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Roberto T Sudo et al.
The journal of pain : official journal of the American Pain Society, 11(1), 71-78 (2009-10-27)
Finding new chemicals or adjuvants with analgesic effects in the central nervous system is clinically relevant due to the limited number of drugs with these properties. Here, we present PT-31, which is chemically related to 3-benzyl-imidazolidine, with an analgesic profile
Zoltán S Zádori et al.
Neurochemistry international, 51(5), 297-305 (2007-08-01)
The inhibitory effect of clonidine (non-selective alpha2-adrenoceptor agonist) and oxymetazoline (alpha2A-adrenoceptor selective agonist) was compared on basal and stimulated gastric motor activity (gastric tone and contractions) using the balloon method in the rat. It was shown that oxymetazoline (0.2-1.7 micromol/kg
Mu-huo Ji et al.
Cytokine, 60(3), 639-645 (2012-09-11)
To investigate the effects of α2A-adrenoreceptor blockade on acute lung injury (ALI) and high mobility group box-1 protein (HMGB1) expression in a rat model of sepsis. Sepsis was induced in male rats by cecal ligation and puncture (CLP). Thirty adult
Alfonso Romero-Sandoval et al.
Anesthesiology, 104(2), 351-355 (2006-01-27)
Partial sciatic nerve ligation (PSNL) produces axonal damage, a local inflammatory response, and wallerian degeneration. Cytokines secreted near the site of nerve injury are thought to play important roles in development and maintenance of central sensitization and neuropathic pain. Injection
Baogang Liu et al.
Neuroreport, 17(12), 1313-1317 (2006-09-05)
Perineural injection of clonidine at the site of nerve injury reduces hypersensitivity while simultaneously reducing leukocyte number and cytokine expression and hyperexcitability in sensory neurons. The activation of p38 mitogen-activated protein kinase in sensory neurons contributes to the development and
商品
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