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文件

B4750

Sigma-Aldrich

Nα-苯甲酰-DL-精氨酸 β-萘胺 盐酸盐

trypsin substrate

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别名:
BANA, Nα-苯甲酰基-DL-精氨酸-2-萘酰胺 盐酸盐
经验公式（希尔记法）:
C23H25N5O2 · HCl
CAS号:
913-04-2
分子量:
439.94
Beilstein:
3823291
EC 号:
213-015-4
MDL编号:
MFCD00038940
PubChem化学物质编号:
24891699
NACRES:
NA.32

质量水平

200

检测方案

≥98% (TLC)

形式

powder

溶解性

DMF: 50 mg/mL, clear, colorless to faintly yellow

储存温度

2-8°C

SMILES字符串

Cl[H].NC(=N)NCCCC(NC(=O)c1ccccc1)C(=O)Nc2ccc3ccccc3c2

InChI

1S/C23H25N5O2.ClH/c24-23(25)26-14-6-11-20(28-21(29)17-8-2-1-3-9-17)22(30)27-19-13-12-16-7-4-5-10-18(16)15-19;/h1-5,7-10,12-13,15,20H,6,11,14H2,(H,27,30)(H,28,29)(H4,24,25,26);1H

InChI key

BNGRKDJZQIGWQF-UHFFFAOYSA-N

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应用

Nα-苯甲酰基-DL-精氨酸β-萘酰胺盐酸盐在BANA试验中作为底物用于评价Stefin的抑制活性。它也已用作测定胰蛋白酶抑制剂Ki值的底物。

生化/生理作用

Nα-苯甲酰基-DL-精氨酸-β萘酰胺盐酸盐（BANA）有助于测定组织蛋白酶B和木瓜蛋白酶的活性。BANA测试也有助于确定牙周致病菌的牙周部位数量。由口腔细菌在牙菌斑或舌苔中合成的挥发性硫化物（VSC）的存在可以通过其水解N-苯甲酰基-DL-精氨酸-2-萘酰胺的能力进行比色确认。

底物

胰蛋白酶的显色底物。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Neera Raghav et al.
Bioorganic chemistry, 75, 38-49 (2017-09-16)
Cathepsins have emerged as promising molecular targets in a number of diseases such as Alzeimer's, inflammation and cancer. Elevated cathepsin's levels and decreased cellular inhibitor concentrations have emphasized the search for novel inhibitors of cathepsins. The present work is focused
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The validity of using pretreatment Periodontal Screening and Recording (PSR) index sextant scores to estimate periodontal access surgery needs is evaluated in patients with chronic periodontitis before and after completion of non-surgical periodontal therapy. In 110 adults, pretreatment probing data
Marie-Hélène Weech et al.
Journal of experimental botany, 59(9), 2437-2448 (2008-05-20)
Arabidopsis thaliana (L.) Heynh. genotypes limited in their ability to mount either octadecanoid-dependent induced resistance (IR(-)) or systemic acquired resistance (SAR(-)) were used to characterize the roles of these pathways in plant-herbivore interactions. Molecular and biochemical markers of IR were
Biochemical and biological properties of leukocyte intracellular inhibitors of proteinases
Macrophages and Lymphocytes, 15(1), 75-83 (1980)
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Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 22(8), 740-746 (2017-06-01)
Although the association between periodontal disease (PD) and adverse pregnancy outcomes has gained recognition amongst antenatal healthcare workers, not much has changed in practice to address it. This prospective study tested the hypothesis that BANA (N-benzoyl-DL-arginine-2-naphthylamide), a diagnostic test for
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