The antibody shows ~5% cross-reactivity with recombinant human β−NGF and recombinant rat β−NGF.

Recombinant human BDNF, expressed in Sf 21 cells.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

Brain derived neurotrophic factor (BDNF) belongs to a family of secreted proteins called neurotrophins that includes, nerve growth factor (NGF), neurotrophin-3 (NT3) and NT4/5. BDNF is expressed in the developing and the mature brain. The downstream pathways promoted by BDNF include PI3K, MAPK and JAK/STAT. The most important role of BDNF is the regulation of synaptic transmission and plasticity, protein synthesis and phosphorylation of local proteins.

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Purified from ascites fluid using protein A.

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