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B5150

杆菌肽 锌盐

from Bacillus licheniformis, ~70,000 U/g

别名:

杆菌肽锌

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关于此项目

经验公式（希尔记法）:
C66H101N17O16SZn
化学文摘社编号:
1405-89-6
分子量:
1486.07
NACRES:
NA.85
PubChem Substance ID:
57653938
UNSPSC Code:
51282002
EC Number:
215-787-8
MDL number:
MFCD00130598
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biological source

Bacillus licheniformis

Quality Level

200

form

powder

specific activity

~70,000 U/g

mp

250 °C (dec.) (lit.)

antibiotic activity spectrum

Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

[Zn++].CCC(C)C(N)C1=NCC(S1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC([O-])=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H]2CCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CC([O-])=O)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](Cc4ccccc4)NC(=O)[C@@H](NC(=O)[C@@H](CCCN)NC2=O)[C@@H](C)CC

InChI

1S/C66H103N17O16S.Zn/c1-9-35(6)52(69)66-72-32-48(100-66)63(97)80-43(26-34(4)5)59(93)75-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)76-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-73-39)77-60(94)44(27-38-18-13-12-14-19-38)81-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)74-56(40)90;/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,73)(H,71,89)(H,74,90)(H,75,93)(H,76,98)(H,77,94)(H,78,96)(H,79,95)(H,80,97)(H,81,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88);/q;+2/p-2/t35?,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48?,52?,53-,54-;/m0./s1

InChI key

NKULICGUDKGGRL-FCHFGNCGSA-L

General description

Chemical structure: peptide

Application

Bacitracin zinc salt is a peptide antibiotic used to study dysruption of bacterial cell wall synthesis at the level of peptidoglycan biosynthesis and isoprenyl metabolism. It is used to study the biosynthesis of sterols and squalene.

Biochem/physiol Actions

Bacitracin is a protease inhibitor. Antimicrobial spectrum: Gram-positive bacteria.
Mode of Action: Inhibits bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000532244
0000532244
0000462288
0000462302
0000462302

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Mechanism of bacitracin action: a specific lipid-peptide interaction.
D R Storm
Annals of the New York Academy of Sciences, 235(0), 387-398 (1974-05-10)
Tritium--hydrogen exchange of bacitracin A. Evidence for an intramolecular hydrogen bond.
R E Galardy et al.
Biochemistry, 10(13), 2429-2436 (1971-06-22)
Bacitracin: an inhibitor of the dephosphorylation of lipid pyrophosphate, an intermediate in the biosynthesis of the peptidoglycan of bacterial cell walls.
G Siewert et al.
Proceedings of the National Academy of Sciences of the United States of America, 57(3), 767-773 (1967-03-01)
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全球贸易项目编号

货号GTIN
B5150-1250KU04061833617113
B5150-250KU04061833433607