B5416
8-溴-环二磷酸腺苷核糖
85% (HPLC), lyophilized powder
别名:
Br-cADP-ribose, Br-cADPR
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关于此项目
经验公式（希尔记法）:
C15H20BrN5O13P2
化学文摘社编号:
分子量:
620.20
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.51
MDL number:
产品名称
8-溴-环二磷酸腺苷核糖, 85% (HPLC), lyophilized powder
SMILES string
Nc1ncnc2n([C@@H]3O[C@@H]4COP(O)(=O)OP(=O)(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H]5O)O[C@H]4[C@H]3O)c(Br)nc12
InChI key
PLQQKRPSINJWTK-VNMBDIRDSA-N
InChI
1S/C15H20BrN5O13P2/c16-15-20-6-11(17)18-3-19-12(6)21(15)13-9(25)10-5(30-13)2-29-35(26,27)34-36(28,32-10)33-14-8(24)7(23)4(1-22)31-14/h3-5,7-10,13-14,22-25H,1-2H2,(H,26,27)(H2,17,18,19)/t4-,5-,7-,8-,9-,10-,13-,14+,36?/m1/s1
assay
85% (HPLC)
form
lyophilized powder
color
white
solubility
H2O: 5 mg/mL
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
环二磷酸腺苷核糖 (cADPR) 的拮抗剂，β-NAD+ 的内源性代谢物。cADPR 已显示出可调节内质网和肌浆网的钙释放。在细胞中，cADPR 是由 ADP-核糖基环化酶或淋巴细胞分化抗原 CD38 合成。
Physical form
含 10-20% 磷酸钠缓冲盐的冻干粉
Preparation Note
酶法制备
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
P Lahouratate et al.
The American journal of physiology, 273(3 Pt 2), H1082-H1089 (1997-10-10)
Cyclic ADP-ribose (cADPR), an endogenous metabolite of beta-NAD+, activates Ca2+ release from endoplasmic reticulum in sea urchin eggs via the ryanodine receptor (RyR) pathway. A similar role has been proposed in cardiac sarcoplasmic reticulum (SR), although this remains controversial. We
H C Lee et al.
Advances in experimental medicine and biology, 419, 411-419 (1997-01-01)
Mobilization of internal Ca+2 is an important signaling mechanism in cells. In addition to the inositol trisphosphate pathway, cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide (NAADP) have been shown to mobilize Ca+2 via independent mechanisms. Although the structures of
H C Lee
Cell biochemistry and biophysics, 28(1), 1-17 (1997-12-05)
Ca2+ mobilization as a signaling mechanism has been placed on center stage with the discovery of the first Ca2+ messenger, inositol trisphosphate (IP3). This article focuses on two new Ca2+ release activators, which mobilize internal Ca2+ stores via mechanisms totally
A De Flora et al.
The international journal of biochemistry & cell biology, 29(10), 1149-1166 (1998-01-23)
CD38 was first identified as a lymphocyte differentiation antigen that showed typical properties of an orphan receptor involved in many programs of cell proliferation and activation. However, CD38 proved also to be a bifunctional ectoenzyme that catalyzes the transient formation
S Iino et al.
Circulation research, 81(5), 879-884 (1997-11-14)
Although it is becoming widely accepted that cADP-ribose (cADPR) can regulate calcium release from the endoplasmic reticulum in sea urchin eggs and in a variety of mammalian cell types, it remains controversial whether this substance might influence calcium release during
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