B6060
BVT.948
≥98% (HPLC), solid
别名:
4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione
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关于此项目
经验公式（希尔记法）:
C14H11NO3
化学文摘社编号:
分子量:
241.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
BVT.948, ≥98% (HPLC), solid
InChI
1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6,17H,1-2H3
SMILES string
CC1(C)C(=O)N=C2c3ccccc3C(=O)C(O)=C12
InChI key
BAQXWJQSUXZVIP-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
protect from light
under inert gas
color
red
solubility
DMSO: 18 mg/mL
H2O: insoluble
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro.
Features and Benefits
BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro.
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Tomasz Warzecha et al.
The plant pathology journal, 35(2), 112-124 (2019-04-23)
Barley worldwide is affected seriously by Fusarium seedling blight (FSB) and Fusarium head blight (FHB) diseases caused by the Fusarium species. The objective of this study was to facilitate the resistance of hulled and hull-less barley at different growth stages
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