B6060
BVT.948
≥98% (HPLC), solid
别名:
4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione
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关于此项目
经验公式（希尔记法）:
C14H11NO3
化学文摘社编号:
分子量:
241.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated, protect from light, under inert gas
Quality Segment
assay
≥98% (HPLC)
form
solid
storage condition
desiccated, protect from light, under inert gas
color
red
solubility
DMSO: 18 mg/mL, H2O: insoluble
storage temp.
−20°C
SMILES string
CC1(C)C(=O)N=C2c3ccccc3C(=O)C(O)=C12
InChI
1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6,17H,1-2H3
InChI key
BAQXWJQSUXZVIP-UHFFFAOYSA-N
Biochem/physiol Actions
BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro.
Features and Benefits
BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro.
警示词
Warning
危险代码
Hazard Classifications
Skin Sens. 1
存储类别
11 - Combustible Solids
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable
PPE（个人防护设备）
dust mask type N95 (US), Eyeshields, Faceshields, Gloves