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B6060

BVT.948

Name: BVT.948
Brand: SIGMA

≥98% (HPLC), solid

别名:

4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione

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关于此项目

经验公式（希尔记法）:

C₁₄H₁₁NO₃

化学文摘社编号:

39674-97-0

分子量:

241.24

NACRES:

NA.77

PubChem Substance ID:

24724422

UNSPSC Code:

12352200

MDL number:

MFCD00616487

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

desiccated, protect from light, under inert gas

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属性

Quality Segment

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated, protect from light, under inert gas

color

red

solubility

DMSO: 18 mg/mL, H₂O: insoluble

storage temp.

−20°C

SMILES string

CC1(C)C(=O)N=C2c3ccccc3C(=O)C(O)=C12

InChI

1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6,17H,1-2H3

InChI key

BAQXWJQSUXZVIP-UHFFFAOYSA-N

说明

Biochem/physiol Actions

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro.

Features and Benefits

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro.