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B6179

米酵菌酸 溶液

from Pseudomonas cocovenenans, ≥95% (HPLC), solution, adenine nucleotide translocase inhibitor

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关于此项目

经验公式（希尔记法）:
C28H38O7
化学文摘社编号:
11076-19-0
分子量:
486.60
UNSPSC Code:
12352106
PubChem Substance ID:
24891898
NACRES:
NA.77
MDL number:
MFCD01729616
Assay:
≥95% (HPLC)
Form:
solution
Quality level:
200
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产品名称

米酵菌酸 溶液, from Pseudomonas cocovenenans, ≥95% (HPLC), ~1 mg/mL

biological source

Pseudomonas cocovenenans

Quality Level

200

assay

≥95% (HPLC)

form

solution

concentration

~1 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

CO[C@H](C/C=C\C=C\CC\C=C\C[C@H](C)\C=C\C(CC(O)=O)=C/C(O)=O)\C(C)=C/C=C(\C)C(O)=O

InChI

1S/C28H38O7/c1-21(15-18-24(19-26(29)30)20-27(31)32)13-11-9-7-5-6-8-10-12-14-25(35-4)22(2)16-17-23(3)28(33)34/h6,8-12,15-19,21,25H,5,7,13-14,20H2,1-4H3,(H,29,30)(H,31,32)(H,33,34)/b8-6+,11-9+,12-10-,18-15+,22-16-,23-17+,24-19+/t21-,25+/m0/s1

InChI key

SHCXABJSXUACKU-WUTQZGRKSA-N

Application

米酵菌酸溶液已被用作腺嘌呤核苷酸转运蛋白(ANT)抑制剂，以发现抑制完整T98G细胞中的氧化磷酸化的其他方法。它还被用作通透转运孔复合物(PTPC)孔抑制剂，以及探索PTPC诱导细胞凋亡作用的工具。

Biochem/physiol Actions

其是一种抗凋亡剂，它可以预防NMDA受体诱导的神经细胞凋亡， 延长病毒载体感染后凋亡细胞的存活，并且可在T细胞中消除由过氧化氢诱导的细胞凋亡。它是腺嘌呤核苷酸转位酶的抑制剂，其是线粒体通透性转换（MPT）孔复合物的组分。米酵菌酸可防止线粒体去极化、肿胀、线粒体外膜破裂、以及细胞色素c等凋亡蛋白的释放。该现象在Stururosporine诱导的Jurkat细胞凋亡过程中，和在TNF-α和乙醇处理后经历凋亡的HepG2中观察到。

Features and Benefits

该化合物是细胞凋亡研究的推荐产品。点击此处，了解更多精选的细胞凋亡产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问sigma.com/discover-bsm。

Physical form

溶于0.01M Tris缓冲液（pH 7.5）中的溶液。

Other Notes

椰毒假单胞菌 的毒性原理。

存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

高风险级别生物产品--病毒，疫苗等

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000241727
0000241727
0000110500
14161102
117M4123V

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全球贸易项目编号

货号GTIN
B6179-.5MG04061833434505