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Merck
CN

B6179

米酵菌酸 溶液

from Pseudomonas cocovenenans, ≥95% (HPLC), solution, adenine nucleotide translocase inhibitor

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关于此项目

经验公式（希尔记法）:
C28H38O7
化学文摘社编号:
11076-19-0
分子量:
486.60
UNSPSC Code:
12352106
PubChem Substance ID:
24891898
NACRES:
NA.77
MDL number:
MFCD01729616
Assay:
≥95% (HPLC)
Form:
solution
Quality level:
200

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产品名称

米酵菌酸 溶液, from Pseudomonas cocovenenans, ≥95% (HPLC), ~1 mg/mL

SMILES string

CO[C@H](C/C=C\C=C\CC\C=C\C[C@H](C)\C=C\C(CC(O)=O)=C/C(O)=O)\C(C)=C/C=C(\C)C(O)=O

InChI

1S/C28H38O7/c1-21(15-18-24(19-26(29)30)20-27(31)32)13-11-9-7-5-6-8-10-12-14-25(35-4)22(2)16-17-23(3)28(33)34/h6,8-12,15-19,21,25H,5,7,13-14,20H2,1-4H3,(H,29,30)(H,31,32)(H,33,34)/b8-6+,11-9+,12-10-,18-15+,22-16-,23-17+,24-19+/t21-,25+/m0/s1

InChI key

SHCXABJSXUACKU-WUTQZGRKSA-N

biological source

Pseudomonas cocovenenans

assay

≥95% (HPLC)

form

solution

concentration

~1 mg/mL

shipped in

wet ice

storage temp.

−20°C

Quality Level

200

相关类别

Application

米酵菌酸溶液已被用作腺嘌呤核苷酸转运蛋白(ANT)抑制剂，以发现抑制完整T98G细胞中的氧化磷酸化的其他方法。它还被用作通透转运孔复合物(PTPC)孔抑制剂，以及探索PTPC诱导细胞凋亡作用的工具。

Biochem/physiol Actions

其是一种抗凋亡剂，它可以预防NMDA受体诱导的神经细胞凋亡， 延长病毒载体感染后凋亡细胞的存活，并且可在T细胞中消除由过氧化氢诱导的细胞凋亡。它是腺嘌呤核苷酸转位酶的抑制剂，其是线粒体通透性转换（MPT）孔复合物的组分。米酵菌酸可防止线粒体去极化、肿胀、线粒体外膜破裂、以及细胞色素c等凋亡蛋白的释放。该现象在Stururosporine诱导的Jurkat细胞凋亡过程中，和在TNF-α和乙醇处理后经历凋亡的HepG2中观察到。

Features and Benefits

该化合物是细胞凋亡研究的推荐产品。点击此处，了解更多精选的细胞凋亡产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问sigma.com/discover-bsm。

Other Notes

椰毒假单胞菌 的毒性原理。

Physical form

溶于0.01M Tris缓冲液（pH 7.5）中的溶液。

存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

高风险级别生物产品--病毒，疫苗等
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000241727
0000241727
0000110500
14161102
117M4123V

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J L Scarlett et al.
FEBS letters, 475(3), 267-272 (2000-06-28)
Cytochrome c release from mitochondria is central to apoptosis, but the events leading up to it are disputed. The mitochondrial membrane potential has been reported to decrease, increase or remain unchanged during cytochrome c release. We measured mitochondrial membrane potential
Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3beta, and induction of the mitochondrial-dependent intrinsic caspase pathway
Stoica B A, et al.
Molecular and Cellular Neurosciences, 22(3), 365-382 (2003)
J G Pastorino et al.
Hepatology (Baltimore, Md.), 31(5), 1141-1152 (2000-05-05)
In the present study, tumor necrosis factor-alpha (TNF-alpha) cytotoxicity is shown to be potentiated by ethanol exposure in vitro in the human hepatoma cell line, HepG2, and in rat primary hepatocytes. Exposure of HepG2 cells and primary hepatocytes for 48
A J Mastrangelo et al.
Biotechnology and bioengineering, 65(3), 298-305 (1999-09-15)
Viral expression systems allow for the rapid production of large amounts of recombinant protein in cell culture. In particular, Sindbis virus vectors now exist that make possible the expression of a variety of heterologous proteins in mammalian culture systems. Unfortunately
A Dumont et al.
Oncogene, 18(3), 747-757 (1999-02-16)
Reactive oxygen species (ROS) play an important role in cell death induced by many different stimuli. This study shows that hydrogen peroxide-induced apoptosis in T-cells did not require tyrosine kinase p561ck, phosphatase CD45, the CD95 receptor and its associated Caspase-8.
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