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Merck
CN

B6684

Rp-8-溴-β-苯基-1，N2-乙鸟苷3′,5′-环硫代磷酸酯 钠盐

≥98% (HPLC), powder

别名:

Rp- β-苯基-1，N 2-etheno-8-溴鸟苷3 ′,5′-环一硫代磷酸酯 钠盐, Rp-8-Br-PET-cGMPS

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关于此项目

经验公式（希尔记法）:
C18H14BrN5NaO6PS
化学文摘社编号:
185246-32-6
分子量:
562.27
UNSPSC代码:
41106305
PubChem化学物质编号:
24724424
NACRES:
NA.77

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质量水平

100

方案

≥98% (HPLC)

表单

powder

效能

30 nM Ki

颜色

white to beige

mp

240-300 °C (lit.)

溶解性

H2O: 15 mg/mL at ≤60 °C

储存温度

−20°C

SMILES字符串

O.[Na+].O[C@@H]1[C@@H]2O[P@]([O-])(=S)OC[C@H]2O[C@H]1n3c(Br)nc4C(=O)n5cc(nc5Nc34)-c6ccccc6

InChI

1S/C18H15BrN5O6PS.Na/c19-17-21-11-14(24(17)16-12(25)13-10(29-16)7-28-31(27,32)30-13)22-18-20-9(6-23(18)15(11)26)8-4-2-1-3-5-8;/h1-6,10,12-13,16,25H,7H2,(H,20,22)(H,27,32);/q;+1/p-1/t10-,12-,13-,16-,31-;/m1./s1

InChI key

SVMPQLHYWRTQCX-DBHVCDLJSA-M

相关类别

生化/生理作用

Rp-8-Br-PET-cGMPS是PKG I（Ki = 30 nM）和PKG II的代谢稳定的竞争性抑制剂。阻断cGMP门控视网膜型离子通道（IC50 = 25 μM）。
Rp-8-Br-PET-cGMPS是cGMP依赖性蛋白激酶G的代谢稳定的竞争性抑制剂。可抑制PKG I（Ki = 30 nM）和PKG II，阻断cGMP门控视网膜离子通道（IC50 = 25 μM）。

特点和优势

《受体分类和信号转导》手册的PKA & PKG页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

法律信息

美国专利5,625,056，德国专利4,217,679。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000089194
0000082250
0000016938
0000016216
125M4724V

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