B6684
Rp-8-溴-β-苯基-1，N2-乙鸟苷3′,5′-环硫代磷酸酯 钠盐
≥98% (HPLC), powder
别名:
Rp- β-苯基-1，N 2-etheno-8-溴鸟苷3 ′,5′-环一硫代磷酸酯 钠盐, Rp-8-Br-PET-cGMPS
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关于此项目
经验公式（希尔记法）:
C18H14BrN5NaO6PS
化学文摘社编号:
分子量:
562.27
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77
产品名称
Rp-8-溴-β-苯基-1，N2-乙鸟苷3′,5′-环硫代磷酸酯 钠盐, ≥98% (HPLC), powder
SMILES string
O.[Na+].O[C@@H]1[C@@H]2O[P@]([O-])(=S)OC[C@H]2O[C@H]1n3c(Br)nc4C(=O)n5cc(nc5Nc34)-c6ccccc6
InChI
1S/C18H15BrN5O6PS.Na/c19-17-21-11-14(24(17)16-12(25)13-10(29-16)7-28-31(27,32)30-13)22-18-20-9(6-23(18)15(11)26)8-4-2-1-3-5-8;/h1-6,10,12-13,16,25H,7H2,(H,20,22)(H,27,32);/q;+1/p-1/t10-,12-,13-,16-,31-;/m1./s1
InChI key
SVMPQLHYWRTQCX-DBHVCDLJSA-M
assay
≥98% (HPLC)
form
powder
potency
30 nM Ki
color
white to beige
mp
240-300 °C (lit.)
solubility
H2O: 15 mg/mL at ≤60 °C
storage temp.
−20°C
Quality Level
相关类别
Biochem/physiol Actions
Rp-8-Br-PET-cGMPS是PKG I（Ki = 30 nM）和PKG II的代谢稳定的竞争性抑制剂。阻断cGMP门控视网膜型离子通道（IC50 = 25 μM）。
Rp-8-Br-PET-cGMPS是cGMP依赖性蛋白激酶G的代谢稳定的竞争性抑制剂。可抑制PKG I（Ki = 30 nM）和PKG II，阻断cGMP门控视网膜离子通道（IC50 = 25 μM）。
Legal Information
美国专利5,625,056，德国专利4,217,679。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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