B6684
Rp-8-溴-β-苯基-1，N2-乙鸟苷3′,5′-环硫代磷酸酯 钠盐
≥98% (HPLC), powder
别名:
Rp- β-苯基-1，N 2-etheno-8-溴鸟苷3 ′,5′-环一硫代磷酸酯 钠盐, Rp-8-Br-PET-cGMPS
质量水平
方案
≥98% (HPLC)
表单
powder
效能
30 nM Ki
颜色
white to beige
mp
240-300 °C (lit.)
溶解性
H2O: 15 mg/mL at ≤60 °C
储存温度
−20°C
SMILES字符串
O.[Na+].O[C@@H]1[C@@H]2O[P@]([O-])(=S)OC[C@H]2O[C@H]1n3c(Br)nc4C(=O)n5cc(nc5Nc34)-c6ccccc6
InChI
1S/C18H15BrN5O6PS.Na/c19-17-21-11-14(24(17)16-12(25)13-10(29-16)7-28-31(27,32)30-13)22-18-20-9(6-23(18)15(11)26)8-4-2-1-3-5-8;/h1-6,10,12-13,16,25H,7H2,(H,20,22)(H,27,32);/q;+1/p-1/t10-,12-,13-,16-,31-;/m1./s1
InChI key
SVMPQLHYWRTQCX-DBHVCDLJSA-M
相关类别
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Ulrike Beckert et al.
Biochemical and biophysical research communications, 451(4), 497-502 (2014-08-12)
In addition to the well-known second messengers cAMP and cGMP, mammalian cells contain the cyclic pyrimidine nucleotides cCMP and cUMP. The Pseudomonas aeruginosa toxin ExoY massively increases cGMP and cUMP in cells, whereas the Bordetella pertussis toxin CyaA increases cAMP
Jwu-Lai Yeh et al.
Clinical science (London, England : 1979), 132(18), 2045-2058 (2018-09-17)
The physiologic process of postnatal ductus arteriosus (DA) closure consists of vasoconstriction followed by vascular remodeling. We have recently reported that B-type natriuretic peptide (BNP), a potent vasodilator, also has anti-remodeling effects in pulmonary vasculature. However, its effects on DA
An-tao Luo et al.
Acta pharmacologica Sinica, 31(11), 1438-1446 (2010-10-19)
To study the effects and mechanisms by which hyposmotic challenge modulate function of L-type calcium current (I(Ca,L)) in rat ventricular myocytes. The whole-cell patch-clamp techniques were used to record I(Ca,L) in rat ventricular myocytes. Hyposmotic challenge(∼220 mosmol/L) induced biphasic changes
Rut Ferrero et al.
BMC biochemistry, 3, 26-26 (2002-09-28)
Soluble guanylyl cyclase (sGC) is the main receptor for nitric oxide (NO) when the latter is produced at low concentrations. This enzyme exists mainly as a heterodimer consisting of one alpha and one beta subunit and converts GTP to the
Junli Ping et al.
Neural plasticity, 2010, 540940-540940 (2010-01-01)
Long-term potentiation (LTP) at thalamic input synapses to the lateral nucleus of the amygdala (LA) has been proposed as a cellular mechanism of the formation of auditory fear memories. We have previously shown that signaling via ERK/MAPK in both the
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