B6684
Rp-8-溴-β-苯基-1，N2-乙鸟苷3′,5′-环硫代磷酸酯 钠盐
≥98% (HPLC), powder
别名:
Rp- β-苯基-1，N 2-etheno-8-溴鸟苷3 ′,5′-环一硫代磷酸酯 钠盐, Rp-8-Br-PET-cGMPS
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关于此项目
经验公式（希尔记法）:
C18H14BrN5NaO6PS
化学文摘社编号:
分子量:
562.27
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77
SMILES string
O.[Na+].O[C@@H]1[C@@H]2O[P@]([O-])(=S)OC[C@H]2O[C@H]1n3c(Br)nc4C(=O)n5cc(nc5Nc34)-c6ccccc6
InChI
1S/C18H15BrN5O6PS.Na/c19-17-21-11-14(24(17)16-12(25)13-10(29-16)7-28-31(27,32)30-13)22-18-20-9(6-23(18)15(11)26)8-4-2-1-3-5-8;/h1-6,10,12-13,16,25H,7H2,(H,20,22)(H,27,32);/q;+1/p-1/t10-,12-,13-,16-,31-;/m1./s1
InChI key
SVMPQLHYWRTQCX-DBHVCDLJSA-M
assay
≥98% (HPLC)
form
powder
potency
30 nM Ki
color
white to beige
mp
240-300 °C (lit.)
solubility
H2O: 15 mg/mL at ≤60 °C
storage temp.
−20°C
Quality Level
相关类别
Biochem/physiol Actions
Rp-8-Br-PET-cGMPS是PKG I（Ki = 30 nM）和PKG II的代谢稳定的竞争性抑制剂。阻断cGMP门控视网膜型离子通道（IC50 = 25 μM）。
Rp-8-Br-PET-cGMPS是cGMP依赖性蛋白激酶G的代谢稳定的竞争性抑制剂。可抑制PKG I（Ki = 30 nM）和PKG II，阻断cGMP门控视网膜离子通道（IC50 = 25 μM）。
Legal Information
美国专利5,625,056，德国专利4,217,679。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Ulrike Beckert et al.
Biochemical and biophysical research communications, 451(4), 497-502 (2014-08-12)
In addition to the well-known second messengers cAMP and cGMP, mammalian cells contain the cyclic pyrimidine nucleotides cCMP and cUMP. The Pseudomonas aeruginosa toxin ExoY massively increases cGMP and cUMP in cells, whereas the Bordetella pertussis toxin CyaA increases cAMP
Jwu-Lai Yeh et al.
Clinical science (London, England : 1979), 132(18), 2045-2058 (2018-09-17)
The physiologic process of postnatal ductus arteriosus (DA) closure consists of vasoconstriction followed by vascular remodeling. We have recently reported that B-type natriuretic peptide (BNP), a potent vasodilator, also has anti-remodeling effects in pulmonary vasculature. However, its effects on DA
An-tao Luo et al.
Acta pharmacologica Sinica, 31(11), 1438-1446 (2010-10-19)
To study the effects and mechanisms by which hyposmotic challenge modulate function of L-type calcium current (I(Ca,L)) in rat ventricular myocytes. The whole-cell patch-clamp techniques were used to record I(Ca,L) in rat ventricular myocytes. Hyposmotic challenge(∼220 mosmol/L) induced biphasic changes
Rut Ferrero et al.
BMC biochemistry, 3, 26-26 (2002-09-28)
Soluble guanylyl cyclase (sGC) is the main receptor for nitric oxide (NO) when the latter is produced at low concentrations. This enzyme exists mainly as a heterodimer consisting of one alpha and one beta subunit and converts GTP to the
Junli Ping et al.
Neural plasticity, 2010, 540940-540940 (2010-01-01)
Long-term potentiation (LTP) at thalamic input synapses to the lateral nucleus of the amygdala (LA) has been proposed as a cellular mechanism of the formation of auditory fear memories. We have previously shown that signaling via ERK/MAPK in both the
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