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经验公式(希尔记法):
C21H22O9
化学文摘社编号:
分子量:
418.39
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
EC Number:
215-808-0
Beilstein/REAXYS Number:
6077558
MDL number:
产品名称
芦荟素, from Aloe barbadensis Miller leaves, ≥97%
InChI key
AFHJQYHRLPMKHU-OSYMLPPYSA-N
InChI
1S/C21H22O9/c22-6-8-4-10-14(21-20(29)19(28)17(26)13(7-23)30-21)9-2-1-3-11(24)15(9)18(27)16(10)12(25)5-8/h1-5,13-14,17,19-26,28-29H,6-7H2/t13-,14+,17-,19+,20-,21+/m1/s1
SMILES string
OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)[C@H]2c3cccc(O)c3C(=O)c4c(O)cc(CO)cc24
biological source
Aloe barbadensis Miller leaves
assay
≥97%
form
powder
solubility
methanol: 100 mg/mL, clear to very slightly hazy, light yellow to yellow
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
Quality Level
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Application
芦荟苷是一种天然存在于芦荟植物中的非对映异构体 (a/B) 蒽环类化合物,可作为化学预防因子和抗肿瘤药物进行研究。芦荟苷抑制血管生成,增强黑色素生成和调节转谷氨酰胺酶活性。芦荟苷可用于评估其作为选择性磷酸二酯酶抑制剂的活性。芦荟苷 A 作为稳定剂用于制备金银纳米颗粒。
Biochem/physiol Actions
大鼠的泻下活性需要真杆菌菌株条或类似肠道厌氧菌激活,推测是通过转化为芦荟大黄素蒽酮。
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Angelo Gismondi et al.
Amino acids, 38(1), 257-262 (2009-02-13)
The aim of this study was to collect evidences on the role of transglutaminase (TG, E.C.2.3.2.13) in the antineoplastic properties exerted by nimesulide (NMS), a non-steroidal anti-inflammatory drug, on murine B16-F10 melanoma cells. Treatment of melanoma cells with nimesulide produces
Claudio Tabolacci et al.
Life sciences, 87(9-10), 316-324 (2010-07-14)
Aloe-emodin (AE), a natural hydroxyanthraquinone compound, has been reported as a potential anticancer agent. We studied the antineoplastic properties of AE on highly metastatic B16-F10 melanoma murine cells. Cell proliferation was assessed by cell counting and viability was investigated using
Mahmoud A Elsohly et al.
Journal of AOAC International, 90(1), 28-42 (2007-03-22)
Methods using liquid chromatography/mass spectrometry (LC/MS) and LC with diode array detection (DAD) in the UV range (LC/UV) were developed for the determination of low levels of the anthraquinones aloe-emodin and aloin-A (barbaloin) in aloe-based products. The methods were used
Aloin enhances cisplatin antineoplastic activity in B16-F10 melanoma cells by transglutaminase-induced differentiation.
Tabolacci C, Rossi S, Lentini A, et al.
Amino Acids, doi: 10-doi: 10 (2011)
Mi-Young Park et al.
Nutrition research and practice, 2(1), 17-21 (2008-04-01)
Aloin is a physiologically active anthraquinone present in aloe. There are two isomers of aloin, aloin A and aloin B, occurring as a mixture of diastereomers. The objective of this study was to determine the bioavailability and tissue distribution of
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