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B7005

倍他米松

Name: 倍他米松
Brand: SIGMA

synthetic (organic), ≥98%, corticosteroid, powder

别名:

9α-氟-11β,17α,21-三羟基-16β-甲基孕甾-1,4-二烯-3,20-二酮, 9α-氟-16β-甲基-11β,17α,21-三羟基-1,4-孕甾二烯-3,20-二酮, 9α-氟-16β-甲基泼尼松龙

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关于此项目

经验公式（希尔记法）:

C₂₂H₂₉FO₅

化学文摘社编号:

378-44-9

分子量:

392.46

NACRES:

NA.77

PubChem Substance ID:

57653954

UNSPSC Code:

51111800

EC Number:

206-825-4

MDL number:

MFCD00062969

Assay:

≥98%

Form:

powder

Quality level:

100

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属性

产品名称

倍他米松, ≥98%

biological source

synthetic (organic)

Quality Level

100

sterility

non-sterile

assay

≥98%

form

powder

mp

235-237 °C (lit.)

solubility

water: 0.063 g/L at 37 °C

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1

InChI key

UREBDLICKHMUKA-DVTGEIKXSA-N

Gene Information

human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Tnf(21926)
rat ... Ar(24208), Nr3c1(24413), Tnf(24835)

说明

Application

Betamethasone has been used as a corticosteroid (CORT) standard.

Biochem/physiol Actions

Betamethasone, an isomer of dexamethasone is also termed as 9α-fluoro-16β-methyl-11 β,17,21-trihydroxypregna-1,4-dien-3,20-dione or 9α-fluoro-16β-methylprednisolone (27.1.52). It can be used as an anti-itch agent and treating dermatitis and eczema.

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pictograms

GHS08

signalword

Danger

hcodes

H360FD,H373

pcodes

P201 - P202 - P260 - P280 - P308 + P313 - P405

Hazard Classifications

Repr. 1B - STOT RE 2

target_organs

Liver,Kidney,Endocrine system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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Lot/Batch Number

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Corticosteroids

Synthesis of Essential Drugs, 349-363 (2006)

A versatile liquid chromatography-tandem mass spectrometry system for the analysis of different groups of veterinary drugs.

Munoz, P. et al.

Analytica Chimica Acta, 529(1), 137-144 (2005)

Glucocorticoid regulation of human pulmonary surfactant protein-B (SP-B) mRNA stability is independent of activated glucocorticoid receptor.

Ceá C Tillis et al.

American journal of physiology. Lung cellular and molecular physiology, 300(6), L940-L950 (2011-03-15)

Adequate expression of surfactant protein-B (SP-B) is critical in the function of pulmonary surfactant to reduce alveolar surface tension. Expression of SP-B mRNA is restricted to specific lung-airway epithelial cells, and human SP-B mRNA stability is increased in the presence

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全球贸易项目编号

货号	GTIN
B7005-100MG	04061835517695
B7005-500MG	04061835553938