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Merck
CN

B7431

苔藓抑素1

≥99%, Protein kinase C activator, solid

别名:

NSC 339555

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关于此项目

经验公式（希尔记法）:
C47H68O17
化学文摘社编号:
83314-01-6
分子量:
905.03
MDL编号:
MFCD00893832
UNSPSC代码:
12352200
PubChem化学物质编号:
24891991
NACRES:
NA.77

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产品名称

苔藓抑素1, ≥99%, solid

质量水平

100

方案

≥99%

表单

solid

颜色

white

溶解性

DMSO: soluble
ethanol: soluble

储存温度

−20°C

SMILES字符串

[H]\C(C(=O)OC)=C1/C[C@@]2([H])C[C@]3(O)O[C@]([H])(C[C@@H](O)CC(=O)O[C@H](C[C@]4([H])C\C(=C(\[H])C(=O)OC)[C@H](OC(=O)\C=C\C=C\CCC)[C@@](O)(O4)C(C)(C)\C=C\[C@@]([H])(C1)O2)[C@@H](C)O)C[C@H](OC(C)=O)C3(C)C

InChI

1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1

InChI key

MJQUEDHRCUIRLF-TVIXENOKSA-N

相关类别

应用

苔藓虫素1已用于研究其对小鼠结肠炎等自发性克罗恩病′（CD）的影响。它也已用于研究其作为驱虫药对大鼠中成年鼠管线虫感染的影响。

生化/生理作用

从海洋苔藓虫 Bugula neritina 中分离的大环内酯可首先激活并随后下调蛋白激酶C（PKC）。其转移PKCδ 和ε的效果比佛波醇肉豆蔻酸乙酸酯更好。
苔藓虫素(Bry1)是一种大环内酯。这种突触发生性化合物是从海洋苔藓虫多室草苔虫中获得的。Bry1能够逆转突触损失。它可以促进多种神经系统疾病动物模型中的突触成熟。当用于脑室给药时，它具有抗抑郁活性。现已确知Bry1参与保护细胞紧密连接（TJ）、抗炎功能和免疫调节。

其他说明

与水溶液中的玻璃和塑料结合

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCZ6729
MKCZ6728
MKCX7100
MKCV6265
MKCW8251

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N Kedei et al.
Biochemical pharmacology, 85(3), 313-324 (2012-11-14)
Bryostatin 1, like the phorbol esters, binds to and activates protein kinase C (PKC) but paradoxically antagonizes many but not all phorbol ester responses. Previously, we have compared patterns of biological response to bryostatin 1, phorbol ester, and the bryostatin
Dan Zhao et al.
Cellular immunology, 271(2), 392-400 (2011-09-10)
The majority of melanoma cells express detectable levels of HLA class II proteins, and an increased threshold of cell surface class II is crucial for the stimulation of CD4+ T cells. Bryostatin-1, a protein kinase C (PKC) activator, has been
Yasuyuki Ogawa et al.
The Journal of organic chemistry, 78(1), 104-115 (2012-11-06)
The Prins cyclization of syn-β-hydroxy allylsilanes and aldehydes gives cis-2,6-disubstituted 4-alkylidenetetrahydropyrans as sole products in excellent yields regardless of the aldehyde (R″) or syn-β-hydroxy allylsilane substituent (R') used. By reversing the R″ and R' groups, complementary exocyclic stereocontrol can be
Jarin Hongpaisan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(2), 630-643 (2011-01-14)
Among the pathologic hallmarks of Alzheimer's disease (AD) neurodegeneration, only synaptic loss in the brains of AD patients closely correlates with the degree of dementia in vivo. Here, we describe a molecular basis for this AD loss of synapses: pathological
Maria Eugenia Ariza et al.
The Journal of biological chemistry, 286(1), 24-34 (2010-11-03)
Bryostatin-1 (Bryo-1), a natural macrocyclic lactone, is clinically used as an anti-cancer agent. In this study, we demonstrate for the first time that Bryo-1 acts as a Toll-like receptor 4 (TLR4) ligand. Interestingly, activation of bone marrow-derived dendritic cells (in
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