B7559
BW A4C
≥98% (HPLC)
别名:
N-[(E)-3-(3-Phenoxyphenyl)prop-2-enyl]acetohydroxamic acid
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关于此项目
经验公式（希尔记法）:
C17H17NO3
化学文摘社编号:
分子量:
283.32
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
InChI key
CEUDWZXMLMKPNN-SOFGYWHQSA-N
SMILES string
CC(=O)N(O)C\C=C\c1cccc(Oc2ccccc2)c1
InChI
1S/C17H17NO3/c1-14(19)18(20)12-6-8-15-7-5-11-17(13-15)21-16-9-3-2-4-10-16/h2-11,13,20H,12H2,1H3/b8-6+
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white
mp
79.3-80.1 °C (lit.)
solubility
DMSO: 20 mg/mL
storage temp.
2-8°C
Quality Level
Gene Information
human ... ALOX5(240)
rat ... Alox5(25290)
Biochem/physiol Actions
Selective 5-lipoxygenase (5-LOX) inhibitor. Inhibits synthesis of LTB4.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
I D Brodowsky et al.
European journal of pharmacology, 254(1-2), 43-47 (1994-03-11)
Linoleic acid is converted to 8R-hydroperoxylinoleic acid by the soluble 8R-dioxygenase of the fungus Gaeumannomyces graminis. Effects of different lipoxygenase inhibitors on the 8R-dioxygenase were evaluated. Three hydroxamic acid derivatives were investigated. BW A4C (N-(3-phenoxycinnamyl)acetohydroxamic acid) was the most potent
S A Yasin et al.
Journal of neuroendocrinology, 6(2), 179-184 (1994-04-01)
Interleukin-1 (IL-1) and interleukin-6 (IL-6) have been reported to stimulate the release of corticotrophin-releasing hormone (CRH) in vitro, the response being antagonized by the cyclo-oxygenase inhibitor, indomethacin. The effects of cytokines on the other major ACTH-releasing hormone, vasopressin (AVP), and
S H Oliveira et al.
International archives of allergy and immunology, 111(3), 244-252 (1996-11-01)
Recently we demonstrated that the eosinophil migration into rat peritoneal cavities induced by a large volume of saline is mediated by LTB4 released by the resident macrophages and mast cells. In the present study, we have investigated the involvement of
Inhibition of leucotriene-synthesis improves dorsal skin flap survival in the rat.
L Törkvist et al.
Acta physiologica Scandinavica, 154(4), 511-512 (1995-08-01)
H J Hussey et al.
British journal of cancer, 74(5), 683-687 (1996-09-01)
The potential involvement of lipoxygenase metabolites in the tumour growth stimulatory activity of arachidonic and linoleic acid has been studied using the 5-lipoxygenase inhibitors, BWA4C, BWB70C and Zileuton. In vitro the former two agents were relatively potent inhibitors of growth
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