B7559
BW A4C
≥98% (HPLC)
别名:
N-[(E)-3-(3-Phenoxyphenyl)prop-2-enyl]acetohydroxamic acid
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关于此项目
经验公式（希尔记法）:
C17H17NO3
化学文摘社编号:
分子量:
283.32
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
产品名称
BW A4C, ≥98% (HPLC)
InChI key
CEUDWZXMLMKPNN-SOFGYWHQSA-N
SMILES string
CC(=O)N(O)C\C=C\c1cccc(Oc2ccccc2)c1
InChI
1S/C17H17NO3/c1-14(19)18(20)12-6-8-15-7-5-11-17(13-15)21-16-9-3-2-4-10-16/h2-11,13,20H,12H2,1H3/b8-6+
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white
mp
79.3-80.1 °C (lit.)
solubility
DMSO: 20 mg/mL
storage temp.
2-8°C
Quality Level
Gene Information
human ... ALOX5(240)
rat ... Alox5(25290)
Biochem/physiol Actions
Selective 5-lipoxygenase (5-LOX) inhibitor. Inhibits synthesis of LTB4.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
H J Hussey et al.
British journal of cancer, 70(1), 6-10 (1994-07-01)
The effect of the polyunsaturated fatty acids (PUFAs) linoleic acid (LA) and arachidonic acid (AA) on the growth of two murine colon adenocarcinoma cell lines (MAC26 and MAC13) has been determined both in vitro and in vivo. When the serum
O Werz et al.
Naunyn-Schmiedeberg's archives of pharmacology, 356(4), 441-445 (1998-01-24)
Differentiation of HL-60 cells along the granulocytic lineage by DMSO in the presence of transforming growth factor-beta and low concentrations of 1,25-dihydroxyvitamin D3 leads to the upregulation of 5-lipoxygenase activity in 100,000 g supernatants and intact cells to levels which
G D Jones et al.
Biochemistry, 35(22), 7197-7203 (1996-06-04)
We have used stopped-flow rapid reaction methods, employing both fluorescence and absorbance monitoring, together with HPLC analysis of the products to study the activation of soybean 15-lipoxygenase by 13(S)-hydroperoxy-9, 11(E,Z)-octadecadienoic acid (13-HPOD). When lipoxygenase is mixed with an equimolar concentration
P Montuschi et al.
European journal of pharmacology, 275(1), 31-37 (1995-02-24)
It has been shown previously that both forms of interleukin-1, 1 alpha and 1 beta, produce dose-dependent relaxation of the rat gastric fundus in vitro, accompanied by an increased production and release of eicosanoids. This effect appears to be mediated
C Zuany-Amorim et al.
British journal of pharmacology, 110(2), 917-924 (1993-10-01)
1. The intraperitoneal (i.p.) injection of 1 or 10 micrograms ovalbumin to sensitized Balb/c mice led to an acute histamine release, firstly evidenced 1 min after the challenge and returning to basal levels 30 min thereafter. This phenomenon was unaccompanied
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