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经验公式(希尔记法):
C21H20BrNO6
化学文摘社编号:
分子量:
462.29
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
产品名称
1(S),9(R)-(−)-甲基溴化荷包牡丹碱, ≥98% (HPLC), solid
Quality Segment
assay
≥98% (HPLC)
form
solid
color
white to off-white
solubility
H2O: >10 mg/mL
storage temp.
2-8°C
SMILES string
[Br-].C[N+]1(C)CCc2cc3OCOc3cc2[C@H]1[C@@H]4OC(=O)c5c6OCOc6ccc45
InChI
1S/C21H20NO6.BrH/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)19-12-3-4-14-20(27-10-24-14)17(12)21(23)28-19;/h3-4,7-8,18-19H,5-6,9-10H2,1-2H3;1H/q+1;/p-1/t18-,19+;/m0./s1
InChI key
BWXCECYGGMGBHD-GRTNUQQKSA-M
Application
1(S),9(R)-(-)-Bicuculline methbromide has been used:
- as a γ-aminobutyric acid (GABAA) receptor A antagonist: in cortical neuron culture
- in artificial cerebrospinal fluid (ACSF) formature dentate granule neurons
- in hypothalamic explant cultures
Biochem/physiol Actions
1(S),9(R)-(−)-Bicuculline methbromide is a GABAA receptor antagonist, which blocks Ca2+-activated potassium (SK) channels. It is the water-soluble derivative of (+)-bicuculline.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)

