B7563
BRD7389
≥98% (HPLC)
别名:
1-Phenethylamino-3H-naphtho[1,2,3-de]quinoline-2,7-dione, 1-[(2-Phenylethyl)amino]-naphtho-3H-[1,2,3-de]quinoline-2,7-dione
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关于此项目
经验公式（希尔记法）:
C24H18N2O2
化学文摘社编号:
分子量:
366.41
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
assay
≥98% (HPLC)
form
powder
color
orange
solubility
DMSO: >20 mg/mL
storage temp.
2-8°C
SMILES string
[nH]1c2c3c(c5c([c](c3ccc2)=O)cccc5)c([c]1=O)NCCc4ccccc4
InChI
1S/C24H18N2O2/c27-23-17-10-5-4-9-16(17)21-20-18(23)11-6-12-19(20)26-24(28)22(21)25-14-13-15-7-2-1-3-8-15/h1-12,25H,13-14H2,(H,26,28)
InChI key
XASCINRGTHLHGM-UHFFFAOYSA-N
Biochem/physiol Actions
BRD7389 is an inhibitor of the RSK kinase family.
BRD7398 is a RSK kinase inhibitor that induces insulin expression and differentiation of pancreatic alpha into beta cells. BRD7398 inhibits RSK1, RSK2 and RSK3; IC50 values of 1.5, 2.4 and 1.2 uM, respectively. Treatment of mouse aTC1 cells with BRD7398 induced expression of b-cell markers Pdx1, Pax4, Iapp and Npy and also induced insulin production.
Features and Benefits
This compound is featured on the MAPKAPs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Dana M Gwinn et al.
Cancer cell, 33(1), 91-107 (2018-01-10)
KRAS is a regulator of the nutrient stress response in non-small-cell lung cancer (NSCLC). Induction of the ATF4 pathway during nutrient depletion requires AKT and NRF2 downstream of KRAS. The tumor suppressor KEAP1 strongly influences the outcome of activation of
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| B7563-5MG | 04061832444611 |
| B7563-25MG | 04061832444604 |