跳转至内容
Merck
CN

B7651

布雷菲德菌素 A

from Penicillium brefeldianum, ≥99% (HPLC and TLC), powder, activator of the sphingomyelin cycle

别名:

Nectrolide, γ,4-二羟基-2-(6-羟基-1-庚烯基)-4-环戊烯丁烯酸λ-内酯, Ascotoxin, BFA, 布雷菲德菌素 A, 烟碱

登录 查看组织和合同定价。

选择尺寸

关于此项目

经验公式（希尔记法）:
C16H24O4
化学文摘社编号:
20350-15-6
分子量:
280.36
NACRES:
NA.77
PubChem Substance ID:
24278285
UNSPSC Code:
12352200
MDL number:
MFCD12913297
Beilstein/REAXYS Number:
25191

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

布雷菲德菌素 A, from Penicillium brefeldianum, ≥99% (HPLC and TLC)

InChI

1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1

SMILES string

C[C@H]1CCC\C=C\[C@@H]2C[C@H](O)C[C@H]2[C@H](O)\C=C\C(=O)O1

InChI key

KQNZDYYTLMIZCT-KQPMLPITSA-N

biological source

Penicillium brefeldianum

assay

≥99% (HPLC and TLC)

form

powder

solubility

DMSO: 10 mg/mL

antibiotic activity spectrum

neoplastics

mode of action

protein synthesis | interferes

storage temp.

2-8°C

Quality Level

300

正在寻找类似产品? 访问 产品对比指南

相关类别

Application

布雷菲德菌素A用于：



  • 提高CRISPR基因组编辑效率。
  • 细胞因子生产检测
  • 在细胞培养实验中抑制胞内运输

Biochem/physiol Actions

布雷菲德菌素A可提高CRISPR介导的同源重组修复（HDR）效率。
布雷菲德菌素A（BFA）是一种会破坏高尔基体的结构和功能的真菌代谢产物。BFA是鞘磷脂循环的一种激活剂。已在人类肿瘤细胞中观察到了布雷菲德菌素A介导的细胞凋亡。
破坏高尔基体的结构和功能；鞘磷脂循环的激活剂。

General description

布雷菲德菌素A（BFA）是一种13元大环内酯类真菌代谢产物。 可抑制蛋白与核酸合成。BFA可抑制腺苷核糖基化因子(ARF)上的GDP转化成GTP，从而阻止外被蛋白(β-COP)的结合，最终破坏高尔基体的结构和功能。BFA是鞘磷脂循环的一种激活剂。已在人类肿瘤细胞中观察到了布雷菲德菌素A介导的细胞凋亡。布雷菲德菌素A可提高CRISPR介导的同源重组修复（HDR）效率。 具有多种生物活性，如抗肿瘤、抗病毒、抗生素、抗有丝分裂、抗真菌和抗线虫等。

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

涉药品监管产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000438981
0000438981
0000438974
0000438974
0000432947

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Concise Total Syntheses of (+)-Brefeldin A, Diastereomers and Analogs and Their Biological Activity
Dr. Mikhail K. Klychnikov et.al.,
Chemistry?A European Journal , 1 (2023)
Kensuke Shibata et al.
Blood, 118(3), 586-593 (2011-05-25)
Unlike conventional T cells, which are exported from the thymus as naive cells and acquire effector functions upon antigen encounter in the periphery, a subset of γδ T cells differentiates into effectors that produce IL-17 within the fetal thymus. We
Vyoma K Patel et al.
Atherosclerosis, 263, 15-23 (2017-06-02)
Atherogenesis is dependent upon monocyte influx into the vessel wall. In humans, three monocyte subsets exist, the number and function of which are significantly altered in cardiovascular disease (CVD). Whether such alterations arise in individuals with a perturbed lipid profile
Antonio Riva et al.
Frontiers in physiology, 12, 632502-632502 (2021-03-30)
Immunoregulatory checkpoint receptors (CR) contribute to the profound immunoparesis observed in alcohol-related liver disease (ALD) and in vitro neutralization of inhibitory-CRs TIM3/PD1 on anti-bacterial T-cells can rescue innate and adaptive anti-bacterial immunity. Recently described soluble-CR forms can modulate immunity in
Marco Lepore et al.
Nature communications, 5, 3866-3866 (2014-05-17)
Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize conserved bacterial antigens derived from riboflavin precursors, presented by the non-polymorphic MHC class I-like molecule MR1. Here we show that human MAIT cells are remarkably oligoclonal in both the
查看所有相关文献

商品

Small Molecule CRISPR Enhancers

Modulation of homology-directed repair (HDR) within the context of CRISPR-genome editing has led to the identification of small molecules that enhance CRISPR-mediated HDR efficiency in various cell types.

CRISPR小分子增强剂

业内研究了CRISPR基因组编辑背景下的HDR调控，发现各种细胞类型中增强CRISPR介导的HDR效率的小分子。

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持