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Merck
CN

B7775

[Hyp3]-Bradykinin

≥97% (HPLC), suitable for cell culture

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关于此项目

经验公式(希尔记法):
C50H73N15O12
化学文摘社编号:
分子量:
1076.21
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
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产品名称

[Hyp3]-Bradykinin, ≥97% (HPLC)

InChI key

JXRLHZCEMXTCBN-DIBGMJQNSA-N

SMILES string

N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CO)C(=O)N4CCC[C@H]4C(=O)N[C@@H](Cc5ccccc5)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C50H73N15O12/c51-32(15-7-19-56-49(52)53)45(73)64-22-10-18-38(64)47(75)65-27-31(67)25-39(65)43(71)58-26-40(68)59-34(23-29-11-3-1-4-12-29)41(69)62-36(28-66)46(74)63-21-9-17-37(63)44(72)61-35(24-30-13-5-2-6-14-30)42(70)60-33(48(76)77)16-8-20-57-50(54)55/h1-6,11-14,31-39,66-67H,7-10,15-28,51H2,(H,58,71)(H,59,68)(H,60,70)(H,61,72)(H,62,69)(H,76,77)(H4,52,53,56)(H4,54,55,57)/t31-,32+,33+,34+,35+,36+,37+,38+,39+/m1/s1

assay

≥97% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

color

white

UniProt accession no.

storage temp.

−20°C

Gene Information

rat ... Tac1(24806)

Biochem/physiol Actions

[Hyp3]-Bradykinin is a bradykinin receptor agonist used to differentiate bradykinin receptors in various cells, tissues and species.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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[Structures and functions of kininogen and kinin hydroxyproline derivatives as multi-functional proteins].
H Kato
[Rinsho ketsueki] The Japanese journal of clinical hematology, 30(10), 1690-1693 (1989-10-01)
R Dengler et al.
FEBS letters, 262(1), 111-114 (1990-03-12)
The recently isolated, naturally occurring peptide hormones [Hyp3]-bradykinin and [Hyp3]-Lys-bradykinin were investigated for their agonist activity on solubilized binding sites from human fibroblasts. Both ligands competed with [3H]bradykinin binding in a dose-dependent fashion with potencies similar to bradykinin (BK) and
Y Matsumura et al.
Agents and actions, 29(3-4), 172-180 (1990-03-01)
We have recently found presence of a high concentration of a novel type of kinin, hydroxyprolyl3-bradykinin (Hyp3-BK) in human tumor ascites in addition to conventional bradykinin (BK). Because of their potential physiological activity, it is of interest to know how
H Kato et al.
Agents and actions. Supplements, 38 ( Pt 1), 217-224 (1992-01-01)
Hydroxyprolyl-3-bradykinin was identified in the digest of purified human high molecular weight (H) kininogen with plasma kallikrein. Hydroxyproline was not detected in the heavy and light chains portions of H kininogen, although they include three possible sites for hydroxylation of
D Regoli et al.
Life sciences, 55(10), 735-749 (1994-01-01)
Bradykinin, desArg9BK, some agonist analogues and several antagonists have been tested in isolated organs in order to identify bradykinin B2 receptor subtypes. The initial pharmacological characterization was made in the rabbit jugular vein and the guinea pig ileum, two widely

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