B9180
BW A868C
≥98% (HPLC)
别名:
3-[(2-Cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)- 4-imidazolidineheptanoic acid
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关于此项目
经验公式（希尔记法）:
C25H37N3O5
化学文摘社编号:
分子量:
459.58
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
BW A868C, ≥98% (HPLC)
InChI
1S/C25H37N3O5/c29-22(20-13-7-4-8-14-20)17-26-28-21(15-9-1-2-10-16-23(30)31)24(32)27(25(28)33)18-19-11-5-3-6-12-19/h3,5-6,11-12,20-22,26,29H,1-2,4,7-10,13-18H2,(H,30,31)
SMILES string
OC(CNN1C(CCCCCCC(O)=O)C(=O)N(Cc2ccccc2)C1=O)C3CCCCC3
InChI key
YZJVWSKJHGEIBL-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
film
color
colorless
solubility
DMSO: 5 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
BW A868C is a potent, selective DP prostanoid receptor antagonist.
Features and Benefits
This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
L Oliveira et al.
British journal of pharmacology, 129(3), 509-514 (2000-03-11)
1. Cumulative concentration-effect curves for the selective prostanoid TP receptor agonist U46619 and six isoprostanes were constructed in the human isolated umbilical artery. 2. All compounds except 8-iso-PGF3 alpha produced concentration-dependent contractions. The contractile response to the isoprostanes increased with
Hui Zhao et al.
Peptides, 29(3), 345-349 (2008-01-09)
Met-Arg-Trp (MRW) has been isolated as an inhibitor for angiotensin I-converting enzyme (ACE) from a pepsin-pancreatin digest of spinach ribulose bisphosphate carboxylase/oxygenase (Rubisco) (IC(50)=0.6 microM). It has been reported that hypotensive activity of ACE-inhibitory peptides derived from food proteins are
G Monneret et al.
Blood, 98(6), 1942-1948 (2001-09-06)
Prostaglandin D2 (PGD2) is released following exposure of asthmatics to allergen and acts via the adenylyl cyclase-coupled receptor for PGD2 (DP receptor). In this study, it is reported that human eosinophils possess this receptor, which would be expected to inhibit
Hui Zhao et al.
Prostaglandins & other lipid mediators, 88(3-4), 68-72 (2008-11-15)
We found that prostaglandin (PG) D(2), the most abundant PG produced in the central nervous system (CNS), exhibited anxiolytic-like activity at a dose of 10-100pmol/mouse after intracerebroventricular (i.c.v.) administration in the elevated plus-maze test in mice. A DP(1) receptor-selective agonist
N A Sharif et al.
British journal of pharmacology, 131(6), 1025-1038 (2000-11-18)
1. A potent and highly selective DP prostanoid receptor antagonist radioligand, [(3)H]-cyclohexyl-N-BWA868C (3-benzyl-5-(6-carboxyhexyl)-1-(2-cyclohexyl-2-hydroxyethyl-amino) hydantoin, ([(3)H]-BWA868C)), has been generated for receptor binding and autoradiographic studies. 2. Specific [(3)H]-BWA868C binding to human platelet membranes achieved equilibrium within 60 min at 23 degrees
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