B9636
S-苯甲酰硫胺 O-单磷酸
别名:
苯磷硫胺
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关于此项目
经验公式（希尔记法）:
C19H23N4O6PS
CAS Number:
分子量:
466.45
EC 号:
MDL编号:
UNSPSC代码:
12352116
PubChem化学物质编号:
NACRES:
NA.79
方案
≥98% (TLC)
质量水平
表单
powder or crystals
颜色
white to off-white
储存温度
2-8°C
SMILES字符串
Cc1ncc(CN(C=O)\C(C)=C(/CCOP(O)(O)=O)SC(=O)c2ccccc2)c(N)n1
InChI
1S/C19H23N4O6PS/c1-13(23(12-24)11-16-10-21-14(2)22-18(16)20)17(8-9-29-30(26,27)28)31-19(25)15-6-4-3-5-7-15/h3-7,10,12H,8-9,11H2,1-2H3,(H2,20,21,22)(H2,26,27,28)/b17-13+
InChI key
BTNNPSLJPBRMLZ-GHRIWEEISA-N
一般描述
S-苯甲酰基硫胺 O-单磷酸酯（苯磷硫胺）是两亲性 S-酰基硫胺衍生物。是一种脂溶性维生素。苯磷硫胺含噻唑环。与硫胺素相比，苯磷硫胺具有更高的生物利用度。
应用
S-苯甲酰基硫胺 O-单磷酸酯用于确定其对大鼠骨骼肌缺血和再灌注的影响。
生化/生理作用
S-苯甲酰基硫胺 O-单磷酸酯（苯磷硫胺）是一种治疗剂。有助于预防视网膜病变、神经病变和肾脏病变等糖尿病并发症。苯磷硫胺抑制糖尿病患者糖基化终末产物（AGE）的合成。苯磷硫胺被认为是预防糖尿病神经病变的营养保健产品。
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Alaa Alkhalaf et al.
PloS one, 7(7), e40427-e40427 (2012-07-14)
Formation of advanced glycation endproducts (AGEs), endothelial dysfunction, and low-grade inflammation are intermediate pathways of hyperglycemia-induced vascular complications. We investigated the effect of benfotiamine on markers of these pathways in patients with type 2 diabetes and nephropathy. Patients with type
Lars P Kihm et al.
Journal of the American Society of Nephrology : JASN, 22(5), 914-926 (2011-04-23)
Residual renal function and the integrity of the peritoneal membrane contribute to morbidity and mortality among patients treated with peritoneal dialysis. Glucose and its degradation products likely contribute to the deterioration of the remnant kidney and damage to the peritoneum.
David A Fraser et al.
Diabetes care, 35(5), 1095-1097 (2012-03-27)
To study the effects of long-term oral benfotiamine supplementation on peripheral nerve function and soluble inflammatory markers in patients with type 1 diabetes. The study randomly assigned 67 patients with type 1 diabetes to receive 24-month benfotiamine (300 mg/day) or
The Effect of Benfothiamin and Vitamin D in Ischemia/Reperfusion Model of Rat Skeletal Muscle
Keskin O
The American Journal of Cardiology, 121(8), e4-e4 (2018)
Xiaoli Pan et al.
Neuroscience bulletin, 32(6), 591-596 (2016-10-04)
To date, we still lack disease-modifying therapies for Alzheimer's disease (AD). Here, we report that long-term administration of benfotiamine improved the cognitive ability of patients with AD. Five patients with mild to moderate AD received oral benfotiamine (300 mg daily) over
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