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B9636

S-苯甲酰硫胺 O-单磷酸

Name: S-苯甲酰硫胺 O-单磷酸
Brand: SIGMA

别名:

苯磷硫胺

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关于此项目

经验公式（希尔记法）:

C₁₉H₂₃N₄O₆PS

化学文摘社编号:

22457-89-2

分子量:

466.45

NACRES:

NA.79

PubChem Substance ID:

24892147

UNSPSC Code:

12352116

EC Number:

245-013-4

MDL number:

MFCD00057343

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属性

assay

≥98% (TLC)

Quality Level

200

form

powder or crystals

color

white to off-white

storage temp.

2-8°C

SMILES string

Cc1ncc(CN(C=O)\C(C)=C(/CCOP(O)(O)=O)SC(=O)c2ccccc2)c(N)n1

InChI

1S/C19H23N4O6PS/c1-13(23(12-24)11-16-10-21-14(2)22-18(16)20)17(8-9-29-30(26,27)28)31-19(25)15-6-4-3-5-7-15/h3-7,10,12H,8-9,11H2,1-2H3,(H2,20,21,22)(H2,26,27,28)/b17-13+

InChI key

BTNNPSLJPBRMLZ-GHRIWEEISA-N

说明

General description

S-苯甲酰基硫胺 O-单磷酸酯（苯磷硫胺）是两亲性 S-酰基硫胺衍生物。是一种脂溶性维生素。苯磷硫胺含噻唑环。与硫胺素相比，苯磷硫胺具有更高的生物利用度。

Application

S-苯甲酰基硫胺 O-单磷酸酯用于确定其对大鼠骨骼肌缺血和再灌注的影响。

Biochem/physiol Actions

S-苯甲酰基硫胺 O-单磷酸酯（苯磷硫胺）是一种治疗剂。有助于预防视网膜病变、神经病变和肾脏病变等糖尿病并发症。苯磷硫胺抑制糖尿病患者糖基化终末产物（AGE）的合成。苯磷硫胺被认为是预防糖尿病神经病变的营养保健产品。

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000491943

0000491060

0000480425

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Benfotiamine protects against peritoneal and kidney damage in peritoneal dialysis.

Lars P Kihm et al.

Journal of the American Society of Nephrology : JASN, 22(5), 914-926 (2011-04-23)

Residual renal function and the integrity of the peritoneal membrane contribute to morbidity and mortality among patients treated with peritoneal dialysis. Glucose and its degradation products likely contribute to the deterioration of the remnant kidney and damage to the peritoneum.

Effect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathy.

Alaa Alkhalaf et al.

PloS one, 7(7), e40427-e40427 (2012-07-14)

Formation of advanced glycation endproducts (AGEs), endothelial dysfunction, and low-grade inflammation are intermediate pathways of hyperglycemia-induced vascular complications. We investigated the effect of benfotiamine on markers of these pathways in patients with type 2 diabetes and nephropathy. Patients with type

The effects of long-term oral benfotiamine supplementation on peripheral nerve function and inflammatory markers in patients with type 1 diabetes: a 24-month, double-blind, randomized, placebo-controlled trial.

David A Fraser et al.

Diabetes care, 35(5), 1095-1097 (2012-03-27)

To study the effects of long-term oral benfotiamine supplementation on peripheral nerve function and soluble inflammatory markers in patients with type 1 diabetes. The study randomly assigned 67 patients with type 1 diabetes to receive 24-month benfotiamine (300 mg/day) or

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全球贸易项目编号

货号	GTIN
B9636-250MG	04061833443866