B9934
BTA-1
≥98% (HPLC), solid
别名:
2-（4′-甲胺苯基）苯并噻唑
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关于此项目
经验公式（希尔记法）:
C14H12N2S
化学文摘社编号:
分子量:
240.32
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
生化/生理作用
BTA-1 是 β 的探针-淀粉样蛋白聚集体；荧光硫黄素-T 衍生物；对淀粉样沉积物表现出高亲和力；显示比硫黄素-T 高 50 倍的亲和力；选择性染色 PS1/APP 转基因小鼠大脑中的脑斑块和脑血管淀粉样沉积物，以及 aβAD 患者死后脑组织中的原纤维；穿过血脑屏障。
BTA-1 是一种荧光硫黄素-T 衍生物，对 β 亲和力高 50 倍-淀粉样蛋白聚集体。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Sajjad Molavipordanjani et al.
European journal of medicinal chemistry, 175, 149-161 (2019-05-13)
Six novel 2-arylimidazo[2,1-b]benzothiazole (IBT) derivatives were synthesized as potential tridentate radiotracers for AD imaging purposes. Two of these ligands (6a,b) were successfully labeled with 99mTc radionuclide at high radiochemical purity using fac-[99mTc(CO)3(H2O)3]+ synthon. [99mTc]7a and [99mTc]7b were evaluated as single
Elena Rodriguez-Vieitez et al.
European journal of nuclear medicine and molecular imaging, 42(7), 1119-1132 (2015-04-22)
Pathological studies suggest that neuroinflammation is exacerbated by increased beta-amyloid (Aβ) levels in the brain early in Alzheimer's disease (AD). The time course and relationships between astrocytosis and Aβ deposition were examined using multitracer in vivo positron emission tomography (PET)
Chester A Mathis et al.
Bioorganic & medicinal chemistry letters, 12(3), 295-298 (2002-01-30)
The synthesis of a new lipophilic thioflavin-T analogue (2-[4' -(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [(11)C]-labeled 6 in control mice resulted in high brain uptake. Amyloid deposits were imaged with multiphoton microscopy in the
Alex C Kwan et al.
Optics express, 17(5), 3679-3689 (2009-03-05)
Intrinsic optical emissions, such as autofluorescence and second harmonic generation (SHG), are potentially useful for functional fluorescence imaging and biomedical disease diagnosis for neurodegenerative diseases such as Alzheimer's disease (AD). Here, using multiphoton and SHG microscopy, we identified sources of
Ruiqing Ni et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 59(6), 960-966 (2018-02-09)
Fibrillary tau aggregates in Alzheimer disease and allied neurodegenerative disorders have been visualized in vivo by PET, whereas mechanistic links between PET-detectable tau deposits and neurotoxicity remain elusive. Here, we took advantage of transgenic mouse models of tauopathies to evaluate
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