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Merck
CN

B9935

BMS-345541

≥98% (HPLC), powder

别名:

N-（1,8-二甲基咪唑并[1,2-a] 喹喔啉-4-基）-1,2-乙二胺 盐酸盐

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关于此项目

经验公式（希尔记法）:
C14H17N5 · HCl
化学文摘社编号:
547757-23-3
分子量:
291.78
NACRES:
NA.77
PubChem Substance ID:
24724429
UNSPSC Code:
12352200
MDL number:
MFCD07784499

主要文件

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产品名称

BMS-345541, ≥98% (HPLC), powder

InChI key

MIDKPVLYXNLFGZ-UHFFFAOYSA-N

SMILES string

Cl[H].Cc1ccc2nc(NCCN)c3ncc(C)n3c2c1

InChI

1S/C14H17N5.ClH/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15;/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18);1H

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

solubility

DMSO: 18 mg/mL
H2O: insoluble

originator

Bristol-Myers Squibb

storage temp.

2-8°C

Quality Level

100

相关类别

Application

BMS-345541已用于：
  • 作为IκB 激酶 (IKK) 复合抑制剂，研究其对由自然杀伤 (NK) 细胞产生的干扰素γ (IFN-γ)的影响
  • 作为 IKK 抑制剂，研究其对牙龈成纤维细胞中嗜酸性粒细胞趋化因子和单核细胞趋化蛋白-1 (MCP-1) mRNA 表达的影响
  • 作为核因子 κB (NF-κB) 通路抑制剂，研究其对在人口腔鳞状细胞癌细胞所产生的肿瘤坏死因子α （TNFα)的影响

Biochem/physiol Actions

BMS-345541 具有抗炎特性。它还可以阻断促炎细胞因子的核因子 κB (NF-κB) 依赖性转录。BMS-345541具有抗炎活性，并在某些动物模型中起到阻止骨侵蚀的作用。
BMS-345541是一种 IKB（IKK）变构位点抑制剂。

Features and Benefits

该化合物由Bristol-Myers Squibb开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，请点击此处。
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000192429
0000192430
0000150605
0000150605
0000192430

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James R Burke et al.
The Journal of biological chemistry, 278(3), 1450-1456 (2002-10-31)
The signal-inducible phosphorylation of serines 32 and 36 of I kappa B alpha is critical in regulating the subsequent ubiquitination and proteolysis of I kappa B alpha, which then releases NF-kappa B to promote gene transcription. The multisubunit I kappa
Neety Sahu et al.
JCI insight, 7(20) (2022-10-05)
No disease-modifying drug exists for osteoarthritis (OA). Despite success in animal models, candidate drugs continue to fail in clinical trials owing to the unmapped interpatient heterogeneity and disease complexity. We used a single-cell platform based on cytometry by time-of-flight (cyTOF)
Christina Ward et al.
Tissue barriers, 3(1-2), e982424-e982424 (2015-04-04)
NF-κB (p50/p65) is the best characterized transcription factor known to regulate cell responses to inflammation. However, NF-κB is also constitutively expressed. We used inhibitors of the classical NF-κB signaling pathway to determine whether this transcription factor has a role in
Zhiyang Chen et al.
The Journal of experimental medicine, 216(1), 152-175 (2018-12-12)
Organism aging is characterized by increased inflammation and decreased stem cell function, yet the relationship between these factors remains incompletely understood. This study shows that aged hematopoietic stem and progenitor cells (HSPCs) exhibit increased ground-stage NF-κB activity, which enhances their
Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations.
Rae, et al.
Science immunology, 7, eabn3800-eabn3800 (2023)
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