B9938
毛蕊异黄酮
≥98% (HPLC)
别名:
3′,7-二羟基-4′-甲氧基-异黄酮, 3′-羟基芒柄花素, 胞衬蛋白
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关于此项目
经验公式（希尔记法）:
C16H12O5
化学文摘社编号:
分子量:
284.26
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to light yellow
solubility
methanol: 1 mg/mL, clear, colorless
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
SMILES string
O=C1C(C(C=C2)=CC(O)=C2OC)=COC3=CC(O)=CC=C13
InChI
1S/C16H12O5/c1-20-14-5-2-9(6-13(14)19)15-8-12(18)11-4-3-10(17)7-16(11)21-15/h2-8,17,19H,1H3
InChI key
QAGGICSUEVNSGH-UHFFFAOYSA-N
General description
毛蕊花素是一种植物雌激素，对雌激素表现出激动和拮抗的效果。它是一种异黄酮，是黄芪提取物主要成分。
Application
毛蕊花素已被用于：
- 通过抑制酪氨酸蛋白激酶 Met (c-Met) 的表达来研究其对胶质母细胞瘤的抑制作用
- 通过调节长链非编码RNA，Ewing肉瘤相关转录物1（EWSAT1），分析其对鼻咽癌细胞生长的影响
- 评价其对大鼠心肌缺血模型左心室射血分数的影响
Biochem/physiol Actions
从中药中分离得到异黄酮和植物雌激素。毛蕊异黄酮诱导 HUVEC 血管生成，促进体内和体外雌激素受体阳性细胞增殖。对大鼠胸主动脉也具有血管舒张作用。
毛蕊花素具有多种治疗特性，例如抗炎、抗氧化、抗病毒和神经保护作用。研究表明，它对乳腺癌、骨肉瘤、肝细胞癌和结直肠癌等具有抗癌作用。由于其能够加速血管生成过程和增加血管内皮生长因子 (VEGF) 的表达，因此也被推广为心肌梗塞的可能治疗方法。它已被发现可显示出由低渗透压条件所引起的高渗透性。最后，毛蕊花素也被建议用作治疗缺氧相关血管疾病的前体药物。
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signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Gao Junqing et al.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 35(2), 160-167 (2015-05-16)
To evaluated the effect of calycosin on left ventricular ejection fraction and angiogenesis. Adult male Sprague-Dawley rats were randomly assigned into calycosin-treated groups (0.5, 1, 2, and 4 mg/kg qd), a dimethyl sulfoxide (DMSO), or a sham-operated control group. The
Jian Chen et al.
JPEN. Journal of parenteral and enteral nutrition, 35(6), 763-769 (2011-07-30)
Calycosin is one of main components in the herb radix astragali and is considered a typical phytoestrogen. It has either estrogenic or antiestrogenic effects that mainly depend on estrogen levels in vivo. This study investigated the effects and mechanisms of
Lingping Kong et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 106, 342-348 (2018-07-04)
The incidence of nasopharyngeal carcinoma (NPC) in China is relatively higher than that throughout the rest of the world, and NPC is geographically distributed. Long non-coding RNA (lncRNA) plays a key role in the development of tumors. Recent studies have
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| B9938-10MG | 04061833047019 |