B9938
毛蕊异黄酮
≥98% (HPLC)
别名:
3′,7-二羟基-4′-甲氧基-异黄酮, 3′-羟基芒柄花素, 胞衬蛋白
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关于此项目
经验公式（希尔记法）:
C16H12O5
化学文摘社编号:
分子量:
284.26
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.25
方案
≥98% (HPLC)
表单
powder
颜色
white to light yellow
溶解性
methanol: 1 mg/mL, clear, colorless
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
2-8°C
SMILES字符串
O=C1C(C(C=C2)=CC(O)=C2OC)=COC3=CC(O)=CC=C13
InChI
1S/C16H12O5/c1-20-14-5-2-9(6-13(14)19)15-8-12(18)11-4-3-10(17)7-16(11)21-15/h2-8,17,19H,1H3
InChI key
QAGGICSUEVNSGH-UHFFFAOYSA-N
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一般描述
毛蕊花素是一种植物雌激素，对雌激素表现出激动和拮抗的效果。它是一种异黄酮，是黄芪提取物主要成分。
应用
毛蕊花素已被用于：
- 通过抑制酪氨酸蛋白激酶 Met (c-Met) 的表达来研究其对胶质母细胞瘤的抑制作用
- 通过调节长链非编码RNA，Ewing肉瘤相关转录物1（EWSAT1），分析其对鼻咽癌细胞生长的影响
- 评价其对大鼠心肌缺血模型左心室射血分数的影响
生化/生理作用
从中药中分离得到异黄酮和植物雌激素。毛蕊异黄酮诱导 HUVEC 血管生成，促进体内和体外雌激素受体阳性细胞增殖。对大鼠胸主动脉也具有血管舒张作用。
毛蕊花素具有多种治疗特性，例如抗炎、抗氧化、抗病毒和神经保护作用。研究表明，它对乳腺癌、骨肉瘤、肝细胞癌和结直肠癌等具有抗癌作用。由于其能够加速血管生成过程和增加血管内皮生长因子 (VEGF) 的表达，因此也被推广为心肌梗塞的可能治疗方法。它已被发现可显示出由低渗透压条件所引起的高渗透性。最后，毛蕊花素也被建议用作治疗缺氧相关血管疾病的前体药物。
警示用语：
Warning
危险声明
危险分类
Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Lingping Kong et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 106, 342-348 (2018-07-04)
The incidence of nasopharyngeal carcinoma (NPC) in China is relatively higher than that throughout the rest of the world, and NPC is geographically distributed. Long non-coding RNA (lncRNA) plays a key role in the development of tumors. Recent studies have
Youhua Xu et al.
Journal of ethnopharmacology, 137(1), 359-370 (2011-06-15)
Astragali radix is a traditional Chinese medicine that has long been used for treatment of diabetes and diabetes-associated disease, but its active component and mechanism on the disease is not well defined. Infiltration of leukocytes within the glomeruli and vasculature
Gao Junqing et al.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 35(2), 160-167 (2015-05-16)
To evaluated the effect of calycosin on left ventricular ejection fraction and angiogenesis. Adult male Sprague-Dawley rats were randomly assigned into calycosin-treated groups (0.5, 1, 2, and 4 mg/kg qd), a dimethyl sulfoxide (DMSO), or a sham-operated control group. The
Yi Fan et al.
European journal of pharmacology, 481(1), 33-40 (2003-11-26)
The purpose of the present study was to examine the effects of calycosin, an isoflavonoid isolated from Astragali Radix, on the impairment of barrier function induced by hypoxia in cultured human umbilical vein endothelial cells. Hypoxia induced an increase in
Jian Chen et al.
JPEN. Journal of parenteral and enteral nutrition, 35(6), 763-769 (2011-07-30)
Calycosin is one of main components in the herb radix astragali and is considered a typical phytoestrogen. It has either estrogenic or antiestrogenic effects that mainly depend on estrogen levels in vivo. This study investigated the effects and mechanisms of
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