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Merck
CN

BM0019

BMS-777607

≥98% (HPLC)

别名:

BMS-817378, N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide, N-[4-[(2-Amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide

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关于此项目

经验公式（希尔记法）:
C25H19ClF2N4O4
化学文摘社编号:
1025720-94-8
分子量:
512.89
NACRES:
NA.77
PubChem Substance ID:
329774362
UNSPSC Code:
12352200
MDL number:
MFCD16495773

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InChI

1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33)

SMILES string

ClC1=C(N)N=CC=C1OC2=CC=C(NC(C3=C(OCC)C=CN(C4=CC=C(F)C=C4)C3=O)=O)C=C2F

InChI key

VNBRGSXVFBYQNN-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 25 mg/mL, clear

storage temp.

room temp

Gene Information

human ... MET(4233)

Biochem/physiol Actions

BMS-777607 is an ATP-competitive inhibitor of the Met kinase superfamily with IC50 values of 1.8, 3.9, 4.3, and 1.1 nM, respectively, for Ron, Met, Tyro-3, and AxI kinases. BMS-777607 has been studied in a variety of cancer models and has shown anti-cancer activity, causing increased apoptosis, and decreased proliferation and migration, although it has also been shown to induce polyploidy, which may lead to chemoresistance.
BMS-777607 is an ATP-competitive inhibitor of the Met kinase superfamily.
RON kinase inhibitor (RONi, BMS-777607) decreases recepteur d′origine nantais (RON) signaling. This Met kinase inhibitor represses prostate cancer metastatic phenotype in vitro, induced by hepatocyte growth factor.

Features and Benefits

BMS-777607 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Legal Information

Sold for research purposes only under agreement from BMS.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000055645
0000055644
086M4726V

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Cytokines: Advances in Research and Application: 2011 Edition, 548-548 (2012)
RON kinase inhibition reduces renal endothelial injury in sickle cell disease mice.
Khaibullina A, et al.
Haematologica, 103(5), 787?798-787?798 (2018)
Dana Bohan et al.
PLoS pathogens, 17(11), e1009743-e1009743 (2021-11-20)
Phosphatidylserine (PS) receptors enhance infection of many enveloped viruses through virion-associated PS binding that is termed apoptotic mimicry. Here we show that this broadly shared uptake mechanism is utilized by SARS-CoV-2 in cells that express low surface levels of ACE2.

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