跳转至内容
Merck
CN

BX-0100-30

Human Spinal Motor Neurons

Human iPSC line, Fully differentiated, Healthy Male Control (no known neurological disorders), Cryopreserved

别名:

Lower Motor Neurons

登录 查看组织和合同定价。

选择尺寸

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

biological source

human (iPSC line)

form

frozen liquid

packaging

vial of 1 (contains ≥1 million cells), vial of 1 (contains ≥5 million cells)

technique(s)

cell culture | mammalian: suitable

storage temp.

-140 to -196°C

相关类别

General description

Human iPSC-Derived Spinal Motor Neurons. GFP-expressing neurons also available (BX-0101-30-1M). Required supplements for the final cell differentiation and maturation (sold separately): BX-2100-100uL, BX-2020-100uL, BX-2040-100uL. Located in the spinal cord or at the brain stem within the motor cortex, motor neurons indirectly or directly carry signals to muscles, organs, or glands from the brain. These neurons have one axon with multiple dendrites, and can be classified either as upper motor neurons, which signal between the brain and the spinal cord, or lower motor neurons, which carry signals to muscles from the spinal cord. Related diseases: ALS, SMA, Spinal Cord Injury. Primary neurotransmitter released: Acetylcholine.

Application

Function: Spinal Motor Neurons are adherent and exhibit substantial neurite outgrowth within the first week in culture. Spinal Motor Neurons exhibit pronounced electrophysiological activity after two weeks in culture, as demonstrated by multi-electrode array (MEA) recordings. Calcein staining demonstrates the elaborate processes of the Spinal Motor Neurons in culture.

Features and Benefits

Marker Expression: Fully differentiated Spinal Motor Neurons have high neuronal purity (>90%) and consist of greater than 70% motor neurons. Labeling with the pan-neuronal marker MAP2 (green) and the motor neuron-specific marker FOXP1 (red) highlight the purity of this neuronal product.

存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

新产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our 文件 section.

如需帮助，请联系 客户支持

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

James C Dodge et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(47), 9137-9147 (2020-10-15)
Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease characterized by motor neuron (MN) death. Lipid dysregulation manifests during disease; however, it is unclear whether lipid homeostasis is adversely affected in the in the spinal cord gray matter (GM), and
Lu-Lin Jiang et al.
The Journal of clinical investigation, 129(8), 3103-3120 (2019-05-22)
Mechanisms underlying motor neuron degeneration in amyotrophic lateral sclerosis (ALS) are yet unclear. Specific deletion of the ER-component membralin in astrocytes manifested postnatal motor defects and lethality in mice, causing the accumulation of extracellular glutamate through reducing the glutamate transporter

商品

Protocol Guide: Functional Tri-Culture of iPSC-Derived Human Neurons, Astrocytes, and Microglia

Discover an expert protocol for seeding and tri-culturing iPSC-derived neurons, astrocytes, and microglia in monoculture. Explore high purity cells and culture reagents.

Protocol Guide: Cortical GABAergic Neuron Monoculture

Discover an expert protocol for seeding and culturing cortical GABAergic neurons in monoculture. Explore GABAergic neuron culture cells and reagents.

实验方案

Protocol Guide: Spiny Striatal GABAergic Neuron Monoculture

Discover an expert protocol for seeding and culturing spiny striatal GABAergic neuron in monoculture. Explore spiny GABAergic neurons and culture reagents.

Protocol Guide: Astrocytes Monoculture

Discover an expert protocol for seeding and culturing astrocytes in monoculture. Explore high purity astrocytes and culture reagents.

Protocol Guide: Cortical Glutamatergic Neuron Monoculture

Discover an expert protocol for culturing cortical glutamatergic neurons in monoculture. Explore glutamatergic neurons culture cells and reagents.

Protocol Guide: Neuron and Microglia Co-Culture Assay

Discover an expert protocol for seeding and co-culturing iPSC-derived neurons and microglia in monoculture. Explore high purity cells and culture reagents.

查看所有结果

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持