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Merck
CN

BX-0300-30

Human Cortical Glutamatergic Neurons

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Human iPSC line, Fully differentiated, Healthy Male Control (no known neurological disorders), Cryopreserved

别名:

excitatory neurons

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生物来源

human (iPSC line)

表单

frozen liquid

包装

vial of 1 (contains ≥1 million cells)
vial of 1 (contains ≥5 million cells)

技术

cell culture | mammalian: suitable

储存温度

-140 to -196°C

相关类别

一般描述

Human iPSC-Derived Cortical Glutamatergic Neurons. GFP-expressing neurons also available (BX-0301-30-1M). Required supplements for the final cell differentiation and maturation (sold separately): BX-2300-100uL, BX-2020-100uL, BX-2040-100uL. Glutamatergic neurons product glutamate, one of the main excitatory neurotransmitters in the central nervous system (CNS). These neurons are involved with learning and memory functions and are used to develop therapeutics for diseases such as Alzheimer’s disease, Huntington’s disease, epilepsy, Parkinson’s disease, and more.

应用

Function: Cortical Glutamatergic Neurons exhibit pronounced electrophysiological activity after two weeks in culture, as demonstrated by multi-electrode array (MEA) recordings.

特点和优势

Marker Expression: Fully differentiated Cortical Glutamatergic Neurons have high neuronal purity (>90%) and comprise predominantly excitatory neurons. Labeling with the pan-neuronal marker MAP2 (red) highlights the neuronal purity of these cells. Labelling with the glutamatergic-specific markers CTIP2 (green) and TBR1 (blue) indicates overwhelming presence of glutamatergic neurons. Morphology: Cortical Glutamatergic Neurons exhibit substantial neurite outgrowth within a week in culture and are adherent. Calcein staining (green) demonstrates the characteristic oval cell shape and long processes of Cortical Glutamatergic Neurons in culture. Primary neurotransmitter released: Glutamate.

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Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array
Brett Addison Emery, Shahrukh Khanzada, Xin Hu, Diana Klutsch, Hayder Amin
Journal of Visualized Experiments (2024)

商品

Protocol Guide: Functional Tri-Culture of iPSC-Derived Human Neurons, Astrocytes, and Microglia

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Protocol Guide: Cortical GABAergic Neuron Monoculture

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实验方案

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Protocol Guide: Astrocytes Monoculture

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Protocol Guide: Cortical Glutamatergic Neuron Monoculture

Discover an expert protocol for culturing cortical glutamatergic neurons in monoculture. Explore glutamatergic neurons culture cells and reagents.

Protocol Guide: Neuron and Microglia Co-Culture Assay

Discover an expert protocol for seeding and co-culturing iPSC-derived neurons and microglia in monoculture. Explore high purity cells and culture reagents.

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