生物来源
human (iPSC line)
表单
frozen liquid
包装
vial of 1 (contains ≥1 million cells)
技术
cell culture | mammalian: suitable
储存温度
-140 to -196°C
一般描述
Human iPSC-Derived Spinal Astrocytes. Required products (sold separately): BX-2600-100uL, BX-2020-100uL. Specialized glia that are the majority of the central nervous system (CNS), astrocytes do not conduct electrical signals but promote the health of the CNS through regulating the blood-brain barrier (BBB), excess neurotransmitter clearance, and maintaining ion balance, and more. Related diseases: ALS, SMA, Spinal Cord Injury.
应用
Function: Spinal Astrocytes promote mature motor neuron activity. Co-culturing motor neurons with spinal astrocytes promotes maximal calcium influx within 10 days. Energy and structural support cell for spinal neurons and immune response. Exhibit earlier and higher levels of synchronous firing when co-cultured with spinal motor neurons.
特点和优势
Marker Expression and Morphology: Fully differentiated Spinal Astrocytes express key astrocyte markers GFAP (green) and S100β (red) at >90% and exhibit mature process-bearing morphologies (shown with a DAPI stain).
Labelling by the spinal-specific marker HOXB4 (red) with a Hoescht stain highlights the regional specificity of the Spinal Astrocytes.
Labelling by the spinal-specific marker HOXB4 (red) with a Hoescht stain highlights the regional specificity of the Spinal Astrocytes.
法规信息
新产品
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John J McInnis et al.
Communications biology, 7(1), 1597-1597 (2024-12-01)
Ceramides are lipids that play vital roles in complex lipid synthesis, membrane function, and cell signaling. Disrupted ceramide homeostasis is implicated in cell-death and several neurologic diseases. Ceramides are often analyzed in tissue, but this approach fails to resolve cell-type
Bryan James Black et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11(11), e2303724-e2303724 (2024-01-08)
Classical target-based drug screening is low-throughput, largely subjective, and costly. Phenotypic screening based on in vitro models is increasingly being used to identify candidate compounds that modulate complex cell/tissue functions. Chronic inflammatory nociception, and subsequent chronic pain conditions, affect peripheral
实验方案
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