Name: Acetylethylcholine mustard hydrochloride
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₈H₁₆ClNO₂ · HCl

CAS Number:

103994-00-9

分子量:

230.13

MDL编号:

MFCD00055153

UNSPSC代码:

12352200

PubChem化学物质编号:

329774756

NACRES:

NA.77

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方案

>97% (GC)

表单

powder

储存条件

desiccated

颜色

white

mp

78-81 °C

溶解性

H₂O: >5 mg/mL
ethanol: soluble
methanol: soluble

储存温度

−20°C

SMILES字符串

Cl[H].CCN(CCCl)CCOC(C)=O

InChI

1S/C8H16ClNO2.ClH/c1-3-10(5-4-9)6-7-12-8(2)11;/h3-7H2,1-2H3;1H

InChI key

CHWPASAPXMNLKO-UHFFFAOYSA-N

应用

Acetylethylcholine mustard hydrochloride has been used as a precursor in ethylcholine aziridinium (AF64A) preparation. It has also been used in the pharmacokinetic study to investigate its role in neuromuscular junction (NMJ) signal transmission and function.

生化/生理作用

Acetylethylcholine mustard hydrochloride can reduce the contraction frequency of the myotubes by inhibiting the synthesis of acetylethylcholine (Ach) with the half-maximal inhibitory concentration (IC50) of 1.22 mM.

Acetylethylcholine mustard is a precursor for ethylcholine mustard aziridinium ion (AF-64A); irreversible ligand for the high affinity choline transport system; specific presynaptic long action cholinotoxin; inhibitor of choline acetyl-transferase.

Acetylethylcholine mustard is an irreversible ligand for the high affinity choline transport system; specific presynaptic long action cholinotoxin; inhibitor of choline acetyl-transferase.