C002
(±)-二苯羟乙酸喹咛环酯
powder
别名:
(±)-QNB, (±)-Quinuclidinyl α-hydroxydiphenylacetate
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选择尺寸
关于此项目
经验公式（希尔记法）:
C21H23NO3
化学文摘社编号:
分子量:
337.41
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
powder
Quality level:
InChI
1S/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2
SMILES string
OC(C(=O)OC1CN2CCC1CC2)(c3ccccc3)c4ccccc4
InChI key
HGMITUYOCPPQLE-UHFFFAOYSA-N
form
powder
color
white
solubility
chloroform: soluble (but decomposes within 24 hrs), methanol: stable (for up to two weeks at -20°C.)
εmax
13,500 at 207.4 nm in methanol
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
非选择性蕈毒碱型乙酰胆碱受体拮抗剂。
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
监管及禁止进口产品
此项目有
Diego Muñoz-Torrero et al.
Neuro-degenerative diseases, 10(1-4), 96-99 (2012-01-13)
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Koji Hori et al.
Neuropsychobiology, 63(3), 147-153 (2011-01-14)
Alzheimer's disease (AD) is well known as a disease characterized by degeneration of cholinergic neuronal activity in the brain. It follows that patients with AD would be sensitive to an 'anticholinergic burden', and also that medicine with anticholinergic properties would
M A Siddiqui et al.
Toxicology in vitro : an international journal published in association with BIBRA, 22(7), 1681-1688 (2008-08-02)
Effect of 4-hydroxynonenal (HNE), a long-chain alpha, beta unsaturated aldehyde product, generated by the oxidation of omega-6 polyunsaturated fatty acids on the sensitivity of selected neurotransmitter receptors was studied in PC-12 cells. Cytotoxicity profiling was carried out at varying concentrations
Kylie J Mansfield et al.
The Journal of pharmacology and experimental therapeutics, 328(3), 893-899 (2008-11-26)
Recent studies have described muscarinic receptors on the mucosa and the detrusor of the human urinary bladder. Muscarinic receptor antagonists are effective in the treatment of overactive bladder (OAB), but their site(s) of action and actual therapeutic target are unclear.
Barbara C van Munster et al.
Journal of psychiatric research, 46(10), 1339-1345 (2012-08-01)
Delirium, a frequently occurring, devastating disease, is often underdiagnosed, especially in dementia. Serum anticholinergic activity (SAA) was proposed as a disease marker as it may reflect delirium's important pathogenetic mechanism, cholinergic deficiency. We assessed the association of serum anticholinergic activity
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