C0166
半胱氨酸-甘氨酸
≥85% (TLC), suitable fo HPLC
别名:
L-cysteinyl-glycine
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关于此项目
经验公式（希尔记法）:
C5H10N2O3S
化学文摘社编号:
分子量:
178.21
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.26
产品名称
半胱氨酸-甘氨酸, ≥85% (TLC)
方案
≥85% (TLC)
表单
solid
技术
HPLC: suitable
储存温度
−20°C
SMILES字符串
NC(CS)C(=O)NCC(O)=O
InChI
1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)
InChI key
ZUKPVRWZDMRIEO-UHFFFAOYSA-N
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一般描述
半胱氨酰甘氨酸是一种二肽，为谷胱甘肽分解代谢的副产物。
应用
半胱氨酰甘氨酸用于对羟基汞苯甲酸（PHMB）的衍生化，用紫外可见二极管阵列检测器（RPLC-DAD）进行在线和连续的反相色谱校准。
生化/生理作用
L-半胱氨酸-L-甘氨酸 (Cys-Gly) 用于谷胱甘肽的稳态研究。Cys-Gly 是巯基稳态、氧化应激和金属管理领域研究的重要分子。
半胱氨酰甘氨酸是神经元中谷胱甘肽生物合成的前体。在过渡金属离子存在的条件下，有利于产生活性氧物质。正常的半胱氨酰甘氨酸水平对于维持正常细胞功能至关重要。
其他说明
谷胱甘肽片段
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Dagmar Drogan et al.
Arteriosclerosis, thrombosis, and vascular biology, 30(10), 2053-2058 (2010-07-31)
To investigate the interrelation between plasma γ-glutamyltransferase (GGT) activity, cysteinyl-glycine (Cys-Gly) (ie, a thiol originating from GGT-mediated cleavage of glutathione), and oxidized low-density lipoprotein (oxLDL) with regard to myocardial infarction (MI) risk in a prospective study. Incident cases of MI
Sandra Osburn et al.
Journal of the American Society for Mass Spectrometry, 23(6), 1019-1023 (2012-03-01)
The radical cations of Cys-Gly and Gly-Cys were studied using ion-molecule reactions (IMR), infrared multiple-photon dissociation (IRMPD) spectroscopy, and density functional theory (DFT) calculations. Homolytic cleavage of the S-NO bond of nitrosylated precursors generated radical cations with the radical site
Determination of S-nitrosoglutathione and other nitrosothiols by p-hydroxymercurybenzoate derivatization and reverse phase chromatography coupled with chemical vapor generation atomic fluorescence detection
Bramanti E, et al.
Talanta, 77(2), 684-694 (2008)
Purification and characterization of a Cys-Gly hydrolase from the gastropod mollusk, Patella caerulea
Cappiello M, et al.
Journal of Enzyme Inhibition and Medicinal Chemistry, 31(6), 1560-1565 (2016)
Pawinee Panpetch et al.
BMC plant biology, 21(1), 69-69 (2021-02-03)
Durian (Durio zibethinus L.) is a highly popular fruit in Thailand and several other Southeast Asian countries. It is abundant in essential nutrients and sulphur-containing compounds such as glutathione (GSH) and γ-glutamylcysteine (γ-EC). Cysteinylglycine (Cys-Gly) is produced by GSH catabolism
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