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C0166

半胱氨酸-甘氨酸

Name: 半胱氨酸-甘氨酸
Brand: SIGMA

≥85% (TLC), suitable fo HPLC

别名:

L-cysteinyl-glycine

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关于此项目

经验公式（希尔记法）:

C₅H₁₀N₂O₃S

化学文摘社编号:

19246-18-5

分子量:

178.21

UNSPSC Code:

12352209

PubChem Substance ID:

24892240

NACRES:

NA.26

MDL number:

MFCD00055567

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产品名称

半胱氨酸-甘氨酸, ≥85% (TLC)

Quality Level

200

assay

≥85% (TLC)

form

solid

technique(s)

HPLC: suitable

storage temp.

−20°C

SMILES string

NC(CS)C(=O)NCC(O)=O

InChI

1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)

InChI key

ZUKPVRWZDMRIEO-UHFFFAOYSA-N

General description

半胱氨酰甘氨酸是一种二肽，为谷胱甘肽分解代谢的副产物。

Application

半胱氨酰甘氨酸用于对羟基汞苯甲酸（PHMB）的衍生化，用紫外可见二极管阵列检测器（RPLC-DAD）进行在线和连续的反相色谱校准。

Biochem/physiol Actions

半胱氨酰甘氨酸是神经元中谷胱甘肽生物合成的前体。在过渡金属离子存在的条件下，有利于产生活性氧物质。正常的半胱氨酰甘氨酸水平对于维持正常细胞功能至关重要。

L-半胱氨酸-L-甘氨酸 (Cys-Gly) 用于谷胱甘肽的稳态研究。Cys-Gly 是巯基稳态、氧化应激和金属管理领域研究的重要分子。

Other Notes

谷胱甘肽片段

pictograms

GHS07

signalword

Warning

hcodes

H302,H319

pcodes

P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Plasma gamma-glutamyltransferase, cysteinyl-glycine, and oxidized low-density lipoprotein: a pathway associated with myocardial infarction risk?

Dagmar Drogan et al.

Arteriosclerosis, thrombosis, and vascular biology, 30(10), 2053-2058 (2010-07-31)

To investigate the interrelation between plasma γ-glutamyltransferase (GGT) activity, cysteinyl-glycine (Cys-Gly) (ie, a thiol originating from GGT-mediated cleavage of glutathione), and oxidized low-density lipoprotein (oxLDL) with regard to myocardial infarction (MI) risk in a prospective study. Incident cases of MI

S-to-αC radical migration in the radical cations of Gly-Cys and Cys-Gly.

Sandra Osburn et al.

Journal of the American Society for Mass Spectrometry, 23(6), 1019-1023 (2012-03-01)

The radical cations of Cys-Gly and Gly-Cys were studied using ion-molecule reactions (IMR), infrared multiple-photon dissociation (IRMPD) spectroscopy, and density functional theory (DFT) calculations. Homolytic cleavage of the S-NO bond of nitrosylated precursors generated radical cations with the radical site

Fruit ripening-associated leucylaminopeptidase with cysteinylglycine dipeptidase activity from durian suggests its involvement in glutathione recycling.

Pawinee Panpetch et al.

BMC plant biology, 21(1), 69-69 (2021-02-03)

Durian (Durio zibethinus L.) is a highly popular fruit in Thailand and several other Southeast Asian countries. It is abundant in essential nutrients and sulphur-containing compounds such as glutathione (GSH) and γ-glutamylcysteine (γ-EC). Cysteinylglycine (Cys-Gly) is produced by GSH catabolism

Purification and characterization of a Cys-Gly hydrolase from the gastropod mollusk, Patella caerulea

Cappiello M, et al.

Journal of Enzyme Inhibition and Medicinal Chemistry, 31(6), 1560-1565 (2016)

Fully automated method for simultaneous determination of total cysteine, cysteinylglycine, glutathione and homocysteine in plasma by HPLC with UV absorbance detection.

Rafał Głowacki et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(28), 3400-3404 (2009-06-30)

A fully automated HPLC method for the simultaneous determination of total thiols in plasma samples has been developed. The method involves reductive conversion of disulfides to their reduced counterparts with the use of tris(2-carboxyethyl)phosphine. After reduction the newly formed sulfhydryl

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货号	GTIN
C0166-100MG	04061832884585
C0166-25MG	04061833450277
C0166-250MG	04061832884592

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