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C0253

Sigma-Aldrich

苯丁酸氮芥

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别名:
4- [双(2-氯乙基)氨基]苯丁酸, 4-(4-[2-(2-氯乙基)氨基]苯基)丁酸
经验公式（希尔记法）:
C14H19Cl2NO2
CAS号:
305-03-3
分子量:
304.21
Beilstein:
999011
EC 号:
206-162-0
MDL编号:
MFCD00021783
PubChem化学物质编号:
24278287
NACRES:
NA.77

形式

powder

质量水平

200

储存温度

2-8°C

SMILES字符串

OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl

InChI

1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)

InChI key

JCKYGMPEJWAADB-UHFFFAOYSA-N

基因信息

human ... CYP2D6(1565)

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应用

苯丁酸氮芥已：
  • 用作烷化剂/化疗剂，以研究其对小鼠淀粉样蛋白形成的抗炎作用
  • 用作阳性对照品，以测定白血病小鼠单核巨噬细胞的细胞毒性
  • 用作腺嘌呤特异性DNA烷基化试剂，以为HeLa S3细胞突变特异性DNA烷基化构建多功能共轭物（8950A-Chb(Cl/OH)）

生化/生理作用

苯丁酸氮芥是一种氮芥烷化剂可用作抗癌药物。苯丁酸氮芥可与细胞膜、RNA、DNA和蛋白质结合。它可通过DNA交联表现出抗炎和抗肿瘤活性。苯丁酸氮芥可通过p53-依赖机制显示对慢性淋巴细胞白血病（CLL）的治疗作用。

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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