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Merck
CN

C0253

苯丁酸氮芥

DNA alkylating agent, powder

别名:

4- [双(2-氯乙基)氨基]苯丁酸, 4-(4-[2-(2-氯乙基)氨基]苯基)丁酸

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关于此项目

经验公式（希尔记法）:
C14H19Cl2NO2
化学文摘社编号:
305-03-3
分子量:
304.21
NACRES:
NA.77
PubChem Substance ID:
24278287
UNSPSC Code:
12352200
EC Number:
206-162-0
MDL number:
MFCD00021783
Beilstein/REAXYS Number:
999011
Form:
powder
Quality level:
200

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产品名称

苯丁酸氮芥,

InChI key

JCKYGMPEJWAADB-UHFFFAOYSA-N

InChI

1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)

SMILES string

OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl

form

powder

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... CYP2D6(1565)

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相关类别

Application

苯丁酸氮芥已：
  • 用作烷化剂/化疗剂，以研究其对小鼠淀粉样蛋白形成的抗炎作用
  • 用作阳性对照品，以测定白血病小鼠单核巨噬细胞的细胞毒性
  • 用作腺嘌呤特异性DNA烷基化试剂，以为HeLa S3细胞突变特异性DNA烷基化构建多功能共轭物（8950A-Chb(Cl/OH)）

Biochem/physiol Actions

苯丁酸氮芥是一种氮芥烷化剂可用作抗癌药物。苯丁酸氮芥可与细胞膜、RNA、DNA和蛋白质结合。它可通过DNA交联表现出抗炎和抗肿瘤活性。苯丁酸氮芥可通过p53-依赖机制显示对慢性淋巴细胞白血病（CLL）的治疗作用。

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBF7266V
WXBF4436V
WXBF3026V
BCCH8961
BCCG4515

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Shrabani Barman et al.
Angewandte Chemie (International ed. in English), 55(13), 4194-4198 (2016-02-27)
Among the well-known phototriggers, the p-hydroxyphenacyl (pHP) group has consistently enabled the very fast, efficient, and high-conversion release of active molecules. Despite this unique behavior, the pHP group has been ignored as a delivery agent, particularly in the area of
Takuya Hidaka et al.
Cell chemical biology, 29(4), 690-695 (2021-08-28)
Mutations in mitochondrial DNA (mtDNA) cause mitochondrial diseases, characterized by abnormal mitochondrial function. Although eliminating mutated mtDNA has potential to cure mitochondrial diseases, no chemical-based drugs in clinical trials are capable of selective modulation of mtDNA mutations. Here, we construct
C Muller et al.
Blood, 92(7), 2213-2219 (1998-09-25)
The objective of this study is to investigate the role of DNA-dependent protein kinase (DNA-PK) in the chronic lymphocytic leukemia (CLL) lymphocyte response to nitrogen mustard therapy. DNA-PK is a nuclear serine/threonine kinase that functions in DNA double-strand break repair
Palle J Pedersen et al.
Journal of medicinal chemistry, 52(10), 3408-3415 (2009-05-01)
The synthesis and biophysical characterization of four prodrug ether phospholipid conjugates are described. The lipids are prepared from the anticancer drug chlorambucil and have C16 and C18 ether chains with phosphatidylcholine or phosphatidylglycerol headgroups. All four prodrugs have the ability
Qingyao Shou et al.
Journal of natural products, 76(7), 1384-1387 (2013-07-16)
Two novel alkaloids (parvifloranines A and B), possessing an unusual 11-carbon skeleton linked with amino acids, were isolated from Geijera parviflora, an endemic Australian Rutaceae. Their structures were elucidated by extensive spectroscopic measurements including 2D NMR analyses. Parvifloranine A was
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DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

DNA损伤和修复

DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。

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