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C0253

苯丁酸氮芥

Name: 苯丁酸氮芥
Brand: SIGMA

DNA alkylating agent, powder

别名:

4- [双(2-氯乙基)氨基]苯丁酸, 4-(4-[2-(2-氯乙基)氨基]苯基)丁酸

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关于此项目

经验公式（希尔记法）:

C₁₄H₁₉Cl₂NO₂

化学文摘社编号:

305-03-3

分子量:

304.21

NACRES:

NA.77

PubChem Substance ID:

24278287

UNSPSC Code:

12352200

EC Number:

206-162-0

MDL number:

MFCD00021783

Beilstein/REAXYS Number:

999011

Form:

powder

Quality level:

200

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属性

产品名称

苯丁酸氮芥,

form

powder

Quality Level

200

storage temp.

2-8°C

SMILES string

OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl

InChI

1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)

InChI key

JCKYGMPEJWAADB-UHFFFAOYSA-N

Gene Information

human ... CYP2D6(1565)

说明

Application

苯丁酸氮芥已：

用作烷化剂/化疗剂，以研究其对小鼠淀粉样蛋白形成的抗炎作用
用作阳性对照品，以测定白血病小鼠单核巨噬细胞的细胞毒性
用作腺嘌呤特异性DNA烷基化试剂，以为HeLa S3细胞突变特异性DNA烷基化构建多功能共轭物（8950A-Chb(Cl/OH)）

Biochem/physiol Actions

苯丁酸氮芥是一种氮芥烷化剂可用作抗癌药物。苯丁酸氮芥可与细胞膜、RNA、DNA和蛋白质结合。它可通过DNA交联表现出抗炎和抗肿瘤活性。苯丁酸氮芥可通过p53-依赖机制显示对慢性淋巴细胞白血病（CLL）的治疗作用。

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H315,H319,H335,H350

pcodes

P201 - P202 - P261 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

DNA损伤和修复

DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。

A p-Hydroxyphenacyl-Benzothiazole-Chlorambucil Conjugate as a Real-Time-Monitoring Drug-Delivery System Assisted by Excited-State Intramolecular Proton Transfer.

Shrabani Barman et al.

Angewandte Chemie (International ed. in English), 55(13), 4194-4198 (2016-02-27)

Among the well-known phototriggers, the p-hydroxyphenacyl (pHP) group has consistently enabled the very fast, efficient, and high-conversion release of active molecules. Despite this unique behavior, the pHP group has been ignored as a delivery agent, particularly in the area of

Targeted elimination of mutated mitochondrial DNA by a multi-functional conjugate capable of sequence-specific adenine alkylation.

Takuya Hidaka et al.

Cell chemical biology, 29(4), 690-695 (2021-08-28)

Mutations in mitochondrial DNA (mtDNA) cause mitochondrial diseases, characterized by abnormal mitochondrial function. Although eliminating mutated mtDNA has potential to cure mitochondrial diseases, no chemical-based drugs in clinical trials are capable of selective modulation of mtDNA mutations. Here, we construct

DNA-Dependent protein kinase activity correlates with clinical and in vitro sensitivity of chronic lymphocytic leukemia lymphocytes to nitrogen mustards.

C Muller et al.

Blood, 92(7), 2213-2219 (1998-09-25)

The objective of this study is to investigate the role of DNA-dependent protein kinase (DNA-PK) in the chronic lymphocytic leukemia (CLL) lymphocyte response to nitrogen mustard therapy. DNA-PK is a nuclear serine/threonine kinase that functions in DNA double-strand break repair

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全球贸易项目编号

货号	GTIN
C0253-10G	04061833450321
C0253-1G	04061826690017