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Merck
CN

C0253

Sigma-Aldrich

苯丁酸氮芥

DNA alkylating agent, powder

别名:

4- [双(2-氯乙基)氨基]苯丁酸, 4-(4-[2-(2-氯乙基)氨基]苯基)丁酸

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关于此项目

经验公式（希尔记法）:
C14H19Cl2NO2
化学文摘社编号:
305-03-3
分子量:
304.21
Beilstein:
999011
EC 号:
206-162-0
MDL编号:
MFCD00021783
UNSPSC代码:
12352200
PubChem化学物质编号:
24278287
NACRES:
NA.77

主要文件

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产品名称

苯丁酸氮芥,

表单

powder

质量水平

200

储存温度

2-8°C

SMILES字符串

OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl

InChI

1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)

InChI key

JCKYGMPEJWAADB-UHFFFAOYSA-N

基因信息

human ... CYP2D6(1565)

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相关类别

应用

苯丁酸氮芥已：
  • 用作烷化剂/化疗剂，以研究其对小鼠淀粉样蛋白形成的抗炎作用
  • 用作阳性对照品，以测定白血病小鼠单核巨噬细胞的细胞毒性
  • 用作腺嘌呤特异性DNA烷基化试剂，以为HeLa S3细胞突变特异性DNA烷基化构建多功能共轭物（8950A-Chb(Cl/OH)）

生化/生理作用

苯丁酸氮芥是一种氮芥烷化剂可用作抗癌药物。苯丁酸氮芥可与细胞膜、RNA、DNA和蛋白质结合。它可通过DNA交联表现出抗炎和抗肿瘤活性。苯丁酸氮芥可通过p53-依赖机制显示对慢性淋巴细胞白血病（CLL）的治疗作用。

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBF7266V
WXBF4436V
WXBF3026V
BCCH8961
BCCG4515

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C Muller et al.
Blood, 92(7), 2213-2219 (1998-09-25)
The objective of this study is to investigate the role of DNA-dependent protein kinase (DNA-PK) in the chronic lymphocytic leukemia (CLL) lymphocyte response to nitrogen mustard therapy. DNA-PK is a nuclear serine/threonine kinase that functions in DNA double-strand break repair
Shrabani Barman et al.
Angewandte Chemie (International ed. in English), 55(13), 4194-4198 (2016-02-27)
Among the well-known phototriggers, the p-hydroxyphenacyl (pHP) group has consistently enabled the very fast, efficient, and high-conversion release of active molecules. Despite this unique behavior, the pHP group has been ignored as a delivery agent, particularly in the area of
Takuya Hidaka et al.
Cell chemical biology, 29(4), 690-695 (2021-08-28)
Mutations in mitochondrial DNA (mtDNA) cause mitochondrial diseases, characterized by abnormal mitochondrial function. Although eliminating mutated mtDNA has potential to cure mitochondrial diseases, no chemical-based drugs in clinical trials are capable of selective modulation of mtDNA mutations. Here, we construct
Daniel Catovsky et al.
Clinical lymphoma, myeloma & leukemia, 11 Suppl 1, S2-S6 (2011-11-09)
Although chlorambucil has been used in the management of chronic lymphocytic leukemia (CLL) for 55 years, the optimal dose and treatment duration have not been established. We summarized data from 4 UK randomized CLL trials over the past 30 years
Shmuel Shtrasburg et al.
Autoimmunity reviews, 12(1), 18-21 (2012-08-11)
The mainstay of AA amyloidosis prevention and treatment is suppression of inflammation. In the present study we have tried to determine the efficacy of a variety of anti-inflammatory agents at suppressing AA amyloidosis in a mouse model of the disease.
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DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

DNA损伤和修复

DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。

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