C0292
Calcitonin Gene Related Peptide rat
≥95% (HPLC), powder
别名:
α-CGRP, CGRP-I
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关于此项目
经验公式（希尔记法）:
C162H262N50O52S2
化学文摘社编号:
分子量:
3806.25
UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
产品名称
Calcitonin Gene Related Peptide rat, ≥95% (HPLC), powder
biological source
rat
assay
≥95% (HPLC)
form
powder
mol wt
3803.25-3809.25 Da
technique(s)
cell based assay: suitable
sequence note
Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2
storage temp.
−20°C
Quality Level
Gene Information
rat ... Calca(24241)
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Other Notes
Lyophilized from 0.1% TFA in H2O
Application
Calcitonin Gene Related Peptide rat has been used:
- To study its protective role in lipopolysaccharide (LPS)-induced acute lung injury (ALI).
- To examine the effects of calcitonin gene related peptide (CGRP) and salmon calcitonin (sCT) on gastric lesions and mucosal barrier in stress induced rats.
- To mediate the complement component 5a (C5a) induced mechanical hypersensitivity by activating nerve fibers and influencing non-neuronal cell movement through its receptor.
Biochem/physiol Actions
Calcitonin gene related peptide (CGRP) is a potent vasodilator produced from sensory fibers, acting as transmitters in the peripheral and central nervous system, thereby exerting its role in regulating pain and cardiovascular activity. CGRPs play an important role in regulating systemic blood pressure, and microvascular dilatation and are associated with hyperemia. It stimulates edema in orofacial tissue and its activation in pancreatic β-cells increases plasma levels of pancreatic enzymes. In addition, CGRP also induces DNA synthesis and cell proliferation in endothelial cells.
Potent, long-lasting vasodilator.
Potent, long-lasting vasodilator; activation of CGRP receptors on pancreatic β-cells increases plasma levels of pancreatic enzymes.
General description
Research area: Neuroscience
Calcitonin gene related peptide (CGRP) is a 37 amino acid neuropeptide. It exists in two isoforms α-CGRP and β-CGRP. CGRP is produced by the alternative splicing of the calcitonin gene (CALCA). They are primarily localized in the C and Aδ sensory fibers, but are also present in non-neuronal tissues, like the cardiovascular system.
Calcitonin gene related peptide (CGRP) is a 37 amino acid neuropeptide. It exists in two isoforms α-CGRP and β-CGRP. CGRP is produced by the alternative splicing of the calcitonin gene (CALCA). They are primarily localized in the C and Aδ sensory fibers, but are also present in non-neuronal tissues, like the cardiovascular system.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
Calcitonin gene-related peptide: physiology and pathophysiology
F A Russell, et al.
Physiological Reviews, 94(4), 1099-1142 (2014)
The Role of Calcitonin Gene Related Peptide (CGRP) in Neurogenic Vasodilation and Its Cardioprotective Effects
Kee Z, et al.
Frontiers in Physiology, 9, 1249-1249 (2018)
Exogenous alpha-calcitonin gene-related peptide attenuates lipopolysaccharide-induced acute lung injury in rats
Yang W, et al.
Molecular Medicine Reports, 12(2), 2181-2188 (2015)
Mechanisms underlying mechanical sensitization induced by complement C5a: the roles of macrophages, TRPV1, and calcitonin gene-related peptide receptors
Warwick CA, et al.
Pain, 160(3), 702-711 (2019)
Calcitonin gene-related peptide is a potent vasodilator
Brain SD, et al.
Nature, 313(5997), 54-54 (1985)
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